Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to describe the management of patients with chronic hepatitis C and previous treatment failure.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Describe the management of patients with chronic hepatitis C and previous treatment failure | 6 years |
| Measure | Description | Time Frame |
|---|---|---|
| To know the frequency of the causes for not responding to the previous treatment: lack of adherence to treatment, incomplete dose of antiviral treatment, insufficient treatment duration or treatment resistance. | 6 years | |
| To assess the percentage of patients with previous treatment failure who are not candidates for re-treatment and its causes. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients of both sexes older than 18 years old with hepatitis C who had previously failed to the standard therapy.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Ricard Solà Lamoglia, Dr. | Hospital del Mar | Principal Investigator |
| Ramón Planas Vila, Dr. | Hospital Germans Tries i Pujol, Barcelona | Principal Investigator |
| Javier García-Samaniego, Dr. | Hospital Carlos III, Madrid | Principal Investigator |
| Moisés Diago, Dr. | Hospital General Universitario de Valencia | Principal Investigator |
| Manuel Romero, Dr. | Hospital de Valme, Sevilla | Principal Investigator |
| José Luís Calleja, Dr | Hospital Puerta del Hierro, Madrid | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| H. de Antequera | Antequera | Andalusia | Spain | |||
| H. Puerta de Mar |
Not provided
Not provided
Not provided
Not provided
Not provided
| 6 years |
| To evaluate the implementation of current recommendations based on the cause of the previous therapeutic failure, in patients with chronic hepatitis C in whom a new course of the antiviral treatment is decided to be administered. | 6 years |
| To know the causes of the dose modifications and withdrawal of treatment during the follow-up period in patients who start re-treatment. | 6 years |
| To know the percentage of patients that achieve sustained viral response when implementing the recommendations based on the cause of the previous therapeutic failure. | 6 years |
| To determine the presence of the polymorphism rs12979860 in the gene IL 28B located on chromosome 19. | The rs12979860 polymorphism in the gene IL 28B that is located on chromosome 19 showed to be strongly associated with the development of sustained viral response (SVR) in patients with chronic hepatitis C treated with PEG-IFN-α/RBV. Patients with this polymorphism clear the virus more easily. | 6 |
| Compare the management of patients with chronic hepatitis C prior treatment failure before and after the appearance of new treatments. | 3 |
| Cadiz |
| Andalusia |
| Spain |
| H. Puerto Real | Cadiz | Andalusia | Spain |
| H. Vírgen de las Nieves | Granada | Andalusia | Spain |
| H. Infanta Elena | Huelva | Andalusia | Spain |
| H. de Jaen | Jaén | Andalusia | Spain |
| H. de Jerez | Jerez de la Frontera | Andalusia | Spain |
| H. Carlos Haya | Málaga | Andalusia | Spain |
| H. Vírgen de la Victoria | Málaga | Andalusia | Spain |
| H. de Valme | Seville | Andalusia | Spain |
| H. San Jorge | Huesca | Aragon | Spain |
| H. Clínico de Zaragoza | Zaragoza | Aragon | Spain |
| H. Miquel Servet | Zaragoza | Aragon | Spain |
| H. Son Dureta | Mallorca | Balearic Islands | Spain |
| H. Son Llàtzer | Mallorca | Balearic Islands | Spain |
| H. Manacor | Manacor | Balearic Islands | Spain |
| Hospital del Mar | Barcelona | Barcelona | Spain |
| H. Basurto | Bilbao | Basque Country | Spain |
| H. de Galdakano | Bilbao | Basque Country | Spain |
| H. las Cruces | Bilbao | Basque Country | Spain |
| H. de Donosti | Donostia / San Sebastian | Basque Country | Spain |
| H. Carlos III | Madrid | C de Madrid | Spain |
| H. de Henares | Alcalá de Henares | C. de Madrid | Spain |
| Fundación de Alcorcón | Alcorcón | C. de Madrid | Spain |
| H. de Getafe | Getafe | C. de Madrid | Spain |
| H. 12 de Octubre | Madrid | C. de Madrid | Spain |
| H. Fundación Jiménez Díaz | Madrid | C. de Madrid | Spain |
| H. la Paz | Madrid | C. de Madrid | Spain |
| H. la Princesa | Madrid | C. de Madrid | Spain |
| H. Príncipe de Astúrias | Madrid | C. de Madrid | Spain |
| H. Severo Ochoa | Madrid | C. de Madrid | Spain |
| H. de Móstoles | Móstoles | C. de Madrid | Spain |
| H. Infanta Cristina | Parla | C. de Madrid | Spain |
| H. Infanta Sofía | San Sebastián de los Reyes | C. de Madrid | Spain |
| H. de Alcoy | Alcoy | C. Valenciana | Spain |
| H. General de Alicante | Alicante | C. Valenciana | Spain |
| H. Marina Baixa | Alicante | C. Valenciana | Spain |
| H. de Castellón | Castellon | C. Valenciana | Spain |
| H. de Elche | Elche | C. Valenciana | Spain |
| H. Vega Baja | Orihuela | C. Valenciana | Spain |
| H. Clínico de Valencia | Valencia | C. Valenciana | Spain |
| H. General de Valencia | Valencia | C. Valenciana | Spain |
| H. de Xàtiva | Xàtiva | C. Valenciana | Spain |
| H. Insular | Gran Canaria | Canary Islands | Spain |
| H. Dr. José Molina Orrosos | Lanzarote | Canary Islands | Spain |
| H. Candelaria | Santa Cruz de Tenerife | Canary Islands | Spain |
| H. Dr. Negrín | Santa Cruz de Tenerife | Canary Islands | Spain |
| H. Universitario de Tenerife | Santa Cruz de Tenerife | Canary Islands | Spain |
| H. de Valdecilla | Santander | Cantabria | Spain |
| H. de León | León | Castille and León | Spain |
| H. Comarcal el Bierzo | Ponferrada | Castille and León | Spain |
| H. Clínico de Salamanca | Salamanca | Castille and León | Spain |
| H. Clinico de Valladolid | Valladolid | Castille and León | Spain |
| H. Río Ortega | Valladolid | Castille and León | Spain |
| H. de Albacete | Albacete | Castille-La Mancha | Spain |
| H. Ciudad Real | Ciudad Real | Castille-La Mancha | Spain |
| H. de Cuenca | Cuenca | Castille-La Mancha | Spain |
| H. de Manzanares | Manzanares | Castille-La Mancha | Spain |
| H. Alcázar | Toledo | Castille-La Mancha | Spain |
| H. Vírgen de la Salud | Toledo | Castille-La Mancha | Spain |
| H, de Tomelloso | Tomelloso | Castille-La Mancha | Spain |
| H. de Valdepeñas | Valdepeñas | Castille-La Mancha | Spain |
| H. Germans Trias Pujol | Badalona | Catalonia | Spain |
| H. Clínic | Barcelona | Catalonia | Spain |
| H. Sant Boi | Barcelona | Catalonia | Spain |
| H. Sant Pau | Barcelona | Catalonia | Spain |
| Hospital de Bellvitge | Barcelona | Catalonia | Spain |
| Xarxa Sanitaria i Social de Santa Tecla (Tarragona) | El Vendrell | Catalonia | Spain |
| H. de Figueres | Figueres | Catalonia | Spain |
| H. Josep Trueta | Girona | Catalonia | Spain |
| H. Santa Caterina | Girona | Catalonia | Spain |
| H. General de Igualada | Igualada | Catalonia | Spain |
| H. Sant Joan de Déu de Manresa | Manresa | Catalonia | Spain |
| H. Sant Joan de Déu de Martorell | Martorell | Catalonia | Spain |
| H. Sant Joan de Reus | Reus | Catalonia | Spain |
| H. Parc Taulí de Sabadell | Sabadell | Catalonia | Spain |
| H. Esperit Sant | Santa Coloma de Gramanet | Catalonia | Spain |
| H. Joan XXIII | Tarragona | Catalonia | Spain |
| H. Verge de la Cinta de Tortosa | Tortosa | Catalonia | Spain |
| H. General de Vic | Vic | Catalonia | Spain |
| H. de Viladecans | Viladecans | Catalonia | Spain |
| H. Infanta Cristina | Badajoz | Extremadura | Spain |
| H. San Pedro Alcántara | Cáceres | Extremadura | Spain |
| H. de Coria/Plasencia | Coria | Extremadura | Spain |
| H. de Mérida | Mérida | Extremadura | Spain |
| Complejo Hospitalario Universitario A Coruña | A Coruña | Galicia | Spain |
| Complexo Hospitalario Universitario A Coruña | A Coruña | Galicia | Spain |
| H. Arquitecto Marcide | Ferrol | Galicia | Spain |
| Complexo Hospitalario Ourense | Ourense | Galicia | Spain |
| Complexo Hospitalario Pontevedra | Pontevedra | Galicia | Spain |
| Complexo Hospitalario Universitario de Santiago | Santiago de Compostela | Galicia | Spain |
| Complejo hospitalario Vigo | Vigo | Galicia | Spain |
| H. Meixoeiro | Vigo | Galicia | Spain |
| H. Xeral Cíes | Vigo | Galicia | Spain |
| POVISA | Vigo | Galicia | Spain |
| H. Puerta del Hierro | Madrid | Madrid | Spain |
| H. Santa Mª del Rosell | Cartagena | Murcia | Spain |
| H. de Arritxaca | El Palmar | Murcia | Spain |
| H. de Lorca | Lorca | Murcia | Spain |
| H. General de Múrcia | Murcia | Murcia | Spain |
| H. Morales Messeguer | Murcia | Murcia | Spain |
| H. de Navarra | Pamplona | Navarre | Spain |
| H. Central de Astúrias | Oviedo | Principality of Asturias | Spain |
| H. Vírgen del Rocío | Seville | Sevilla | Spain |
| ID | Term |
|---|---|
| D006526 | Hepatitis C |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D006525 | Hepatitis, Viral, Human |
| D014777 | Virus Diseases |
| D018178 | Flaviviridae Infections |
| D012327 | RNA Virus Infections |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
Not provided
Not provided