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| Name | Class |
|---|---|
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
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This study will be a randomized controlled trial to determine the efficacy of the Otago Exercise Program (OEP) on falls among seniors with a history of falls.
A total of 344 community-dwelling adults aged 70 years and older who are referred to a falls clinic secondary to seeking medical attention due to a fall will be randomized to either the 12-month OEP group or usual care. There will be three measurement sessions: baseline, 6 months, and 12 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | OEP (Otago Exercise Program; home-based balance and strength retraining program) |
|
| 2 | Active Comparator | CON (control; usual care) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Home-based balance and strength retraining exercise program. | Behavioral | A 12-month home-based balance and strength restraining program delivered by a physical therapist |
|
| Measure | Description | Time Frame |
|---|---|---|
| Falls over a 12 month period. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Secondary outcomes of interest include: 1) physiological falls risk; 2) mobility; 3) cognitive function; and 4) economic evaluation. | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Teresa Liu-Ambrose | University of British Columbia | Principal Investigator |
| Karim Khan, Ph.D | University of British Columbia | Study Director |
| Larry Dian, MD | University of British Columbia | Study Director |
| Wendy Cook, MD | University of British Columbia | Study Director |
| Penny Brasher, Ph.D | University of British Columbia | Study Director |
| Carlo Marra, Ph.D | University of British Columbia | Study Director |
| Jennifer Davis, Ph.D | University of British Columbia | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aging, Mobility, and Cognitive Neuroscience Laboratory, Vancouver Falls Prevention Clinic, University of British Columbia | Vancouver | British Columbia | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42226016 | Derived | Davis JC, Falck RS, Hsu CL, Khan K, Chan P, Ghag C, Jacova P, Madden K, Dian L, Rice J, Parmar N, Mitton C, Liu-Ambrose T. Using case-mixes to understand health resource utilization trajectories among older adults at high risk of falls who received baseline geriatrician-based Falls Prevention Clinic care. J Gerontol A Biol Sci Med Sci. 2026 Jun 6;81(7):glag146. doi: 10.1093/gerona/glag146. | |
| 41722333 |
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| control; usual care | Behavioral | Usual care as prescribed by geriatrician. |
|
| Derived |
| Davis JC, Wiley E, Khan KM, Dian L, Madden K, Tai D, Hsu CL, Seo YS, Golbidi M, Liu-Ambrose T. Twelve-month cost analysis of a geriatrician-led falls prevention clinic in Canada. Maturitas. 2026 Apr;207:108862. doi: 10.1016/j.maturitas.2026.108862. Epub 2026 Feb 2. |
| 39561465 | Derived | Falck RS, Hsu CL, Davis JC, Rice J, Dao E, Dian L, Madden K, Skelton DA, Parmar N, Cook WL, Khan KM, Liu-Ambrose T. Effect of a home-based exercise program on subsequent falls among community-dwelling older adults with cognitive frailty: A sub-group analysis of a randomized controlled trial. Maturitas. 2025 Jan;191:108151. doi: 10.1016/j.maturitas.2024.108151. Epub 2024 Nov 7. |
| 35798988 | Derived | Davis JC, Hsu CL, Ghag C, Starkey SY, Jacova P, Dian L, Parmar N, Madden K, Liu-Ambrose T. Baseline health-related quality of life predicts falls: a secondary analysis of a randomized controlled trial. Qual Life Res. 2022 Nov;31(11):3211-3220. doi: 10.1007/s11136-022-03175-2. Epub 2022 Jul 7. |
| 35442974 | Derived | Davis JC, Hsu CL, Barha C, Jehu DA, Chan P, Ghag C, Jacova P, Adjetey C, Dian L, Parmar N, Madden K, Liu-Ambrose T. Comparing the cost-effectiveness of the Otago Exercise Programme among older women and men: A secondary analysis of a randomized controlled trial. PLoS One. 2022 Apr 20;17(4):e0267247. doi: 10.1371/journal.pone.0267247. eCollection 2022. |
| 33225343 | Derived | Liu-Ambrose T, Davis JC, Falck RS, Best JR, Dao E, Vesely K, Ghag C, Rosano C, Hsu CL, Dian L, Cook W, Madden KM, Khan KM. Exercise, Processing Speed, and Subsequent Falls: A Secondary Analysis of a 12-Month Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2021 Mar 31;76(4):675-682. doi: 10.1093/gerona/glaa239. |
| 32472567 | Derived | Davis JC, Khan KM, Hsu CL, Chan P, Cook WL, Dian L, Liu-Ambrose T. Action Seniors! Cost-Effectiveness Analysis of a Secondary Falls Prevention Strategy Among Community-Dwelling Older Fallers. J Am Geriatr Soc. 2020 Sep;68(9):1988-1997. doi: 10.1111/jgs.16476. Epub 2020 May 29. |
| 31162569 | Derived | Liu-Ambrose T, Davis JC, Best JR, Dian L, Madden K, Cook W, Hsu CL, Khan KM. Effect of a Home-Based Exercise Program on Subsequent Falls Among Community-Dwelling High-Risk Older Adults After a Fall: A Randomized Clinical Trial. JAMA. 2019 Jun 4;321(21):2092-2100. doi: 10.1001/jama.2019.5795. |
| 25873254 | Derived | Liu-Ambrose T, Davis JC, Hsu CL, Gomez C, Vertes K, Marra C, Brasher PM, Dao E, Khan KM, Cook W, Donaldson MG, Rhodes R, Dian L. Action seniors! - secondary falls prevention in community-dwelling senior fallers: study protocol for a randomized controlled trial. Trials. 2015 Apr 10;16:144. doi: 10.1186/s13063-015-0648-7. |