Effect of Intraoperative Magnesium on Remifentanil-induced Postoperative Hyperalgesia After Thyroidectomy

The purpose of this study is to study the effect of intraoperative magnesium on remifentanil-induced postoperative hyperalgesia after thyroidectomy

Inclusion Criteria:

• Patients undergoing thyroidectomy,
• Age 20-65,
• American Society of Anesthesiologists physical status classification I or II.

Exclusion Criteria:

• History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs,
• History of drug & alcohol abuse,
• Psychiatric disorder,
• Use of opioids within 24hrs,
• Renal disease with decreased GFR,
• Neuromuscular disease, Severe cardiac disease.