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No recruitment
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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| Society of Nuclear Medicine | UNKNOWN |
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The purpose of this study is to determine abnormal neuro-hormonal mechanisms that may impair the ability to feel full and which therefore, may lead to obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obese | Healthy obese subjects | ||
| Non-obese | Healthy non-obese subjects |
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| Measure | Description | Time Frame |
|---|---|---|
| Cholecystokinin serum level | fasting- state, then at time points 30, 60 and 120 minutes post-meal | |
| Oxytocin serum bioassay | fasting-state, and then at time points of 30, 60 and 120 minutes post-meal | |
| Gastric Emptying time | calculated at time points 0.5, 1,2,3 and 4 hours post-meal | |
| Perception of fullness using visual analog scales | fasting-state, and then at time points of every half hour post-meal through completion of the scan |
| Measure | Description | Time Frame |
|---|---|---|
| Mini International Neuro-psychiatric Interview (MINI) | once within 30 days of the scan |
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Inclusion Criteria:
Exclusion Criteria:
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Community sample, patients of a weight management clinic and patients of Medical University of South Carolina
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| Name | Affiliation | Role |
|---|---|---|
| Kelly A Holes-Lewis, M.D. | Medical University of South Carolina | Principal Investigator |
| Thomas W Uhde, M.D. | Medical University of South Carolina | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of South Carolina | Charleston | South Carolina | 29403 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17986696 | Background | Flegal KM, Graubard BI, Williamson DF, Gail MH. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA. 2007 Nov 7;298(17):2028-37. doi: 10.1001/jama.298.17.2028. | |
| 9771869 | Background | Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults. Am J Clin Nutr. 1998 Oct;68(4):899-917. doi: 10.1093/ajcn/68.4.899. No abstract available. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D001008 | Anxiety Disorders |
| D003863 | Depression |
| D016584 | Panic Disorder |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| 18061414 | Background | Valassi E, Scacchi M, Cavagnini F. Neuroendocrine control of food intake. Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):158-68. doi: 10.1016/j.numecd.2007.06.004. Epub 2007 Dec 3. |
| 12198015 | Background | Burton-Freeman B, Davis PA, Schneeman BO. Plasma cholecystokinin is associated with subjective measures of satiety in women. Am J Clin Nutr. 2002 Sep;76(3):659-67. doi: 10.1093/ajcn/76.3.659. |
| 15082874 | Background | Konturek SJ, Konturek JW, Pawlik T, Brzozowski T. Brain-gut axis and its role in the control of food intake. J Physiol Pharmacol. 2004 Mar;55(1 Pt 2):137-54. |
| 9590372 | Background | Rehfeld JF. Accurate measurement of cholecystokinin in plasma. Clin Chem. 1998 May;44(5):991-1001. |
| 3949984 | Background | Liddle RA, Morita ET, Conrad CK, Williams JA. Regulation of gastric emptying in humans by cholecystokinin. J Clin Invest. 1986 Mar;77(3):992-6. doi: 10.1172/JCI112401. |
| 9138439 | Background | McCann UD, Slate SO, Geraci M, Roscow-Terrill D, Uhde TW. A comparison of the effects of intravenous pentagastrin on patients with social phobia, panic disorder and healthy controls. Neuropsychopharmacology. 1997 Mar;16(3):229-37. doi: 10.1016/S0893-133X(96)00197-2. |
| 19050032 | Background | Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J. Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain. 2009 Mar;132(Pt 3):778-87. doi: 10.1093/brain/awn330. Epub 2008 Dec 2. |
| 19372201 | Background | Moran TH, Dailey MJ. Minireview: Gut peptides: targets for antiobesity drug development? Endocrinology. 2009 Jun;150(6):2526-30. doi: 10.1210/en.2009-0003. Epub 2009 Apr 16. |
| 16340035 | Background | Konturek PC, Konturek JW, Czesnikiewicz-Guzik M, Brzozowski T, Sito E, Konturek SJ. Neuro-hormonal control of food intake: basic mechanisms and clinical implications. J Physiol Pharmacol. 2005 Dec;56 Suppl 6:5-25. |
| 17919488 | Background | Little TJ, Russo A, Meyer JH, Horowitz M, Smyth DR, Bellon M, Wishart JM, Jones KL, Feinle-Bisset C. Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides. Gastroenterology. 2007 Oct;133(4):1124-31. doi: 10.1053/j.gastro.2007.06.060. Epub 2007 Jul 3. |
| 15093695 | Background | Monstein HJ, Grahn N, Truedsson M, Ohlsson B. Oxytocin and oxytocin-receptor mRNA expression in the human gastrointestinal tract: a polymerase chain reaction study. Regul Pept. 2004 Jun 15;119(1-2):39-44. doi: 10.1016/j.regpep.2003.12.017. |
| 12113268 | Background | Ohlsson B, Forsling ML, Rehfeld JF, Sjolund K. Cholecystokinin stimulation leads to increased oxytocin secretion in women. Eur J Surg. 2002;168(2):114-8. doi: 10.1080/11024150252884340. |
| 19243587 | Background | Borg J, Melander O, Johansson L, Uvnas-Moberg K, Rehfeld JF, Ohlsson B. Gastroparesis is associated with oxytocin deficiency, oesophageal dysmotility with hyperCCKemia, and autonomic neuropathy with hypergastrinemia. BMC Gastroenterol. 2009 Feb 25;9:17. doi: 10.1186/1471-230X-9-17. |
| 17601989 | Background | Runge CF. Economic consequences of the obese. Diabetes. 2007 Nov;56(11):2668-72. doi: 10.2337/db07-0633. Epub 2007 Jun 29. |
| 19601481 | Background | Dall TM, Fulgoni VL 3rd, Zhang Y, Reimers KJ, Packard PT, Astwood JD. Potential health benefits and medical cost savings from calorie, sodium, and saturated fat reductions in the American diet. Am J Health Promot. 2009 Jul-Aug;23(6):412-22. doi: 10.4278/ajhp.080930-QUAN-226. |
| 17443025 | Background | Zwirska-Korczala K, Konturek SJ, Sodowski M, Wylezol M, Kuka D, Sowa P, Adamczyk-Sowa M, Kukla M, Berdowska A, Rehfeld JF, Bielanski W, Brzozowski T. Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome. J Physiol Pharmacol. 2007 Mar;58 Suppl 1:13-35. |
| 18287197 | Background | Abell TL, Camilleri M, Donohoe K, Hasler WL, Lin HC, Maurer AH, McCallum RW, Nowak T, Nusynowitz ML, Parkman HP, Shreve P, Szarka LA, Snape WJ Jr, Ziessman HA; American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. J Nucl Med Technol. 2008 Mar;36(1):44-54. doi: 10.2967/jnmt.107.048116. Epub 2008 Feb 20. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |