Vitamin D for Chronic Sinusitis

A Randomized, Clinical Trial of a Novel Immunotherapy for Chronic Sinusitis: Vitamin D

The purpose of this study is to examine if vitamin D improves the symptoms of chronic sinusitis.

Inclusion Criteria:

• African American (4 grandparents with AA ancestry)
• Age>18 years
• Diagnosis of chronic sinusitis

Exclusion Criteria:

• Women of childbearing potential not utilizing contraception
• Subjects with contraindications to vitamin D therapy
• History of nephrolithiasis, hypercalcemia, sarcoidosis, recent (3 month) hospitalization
• Use of immunosuppressants/medications that interfere with vitamin D metabolism (e.g., phenytoin and carbamazepine)
• Malignancy
• Kidney, gastrointestinal, or liver disorders
• Immunodeficiency
• Morbid obesity (BMI>35 kg/m2)
• Changes to medications for 6 months prior to study entry