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The purpose of the study is to test the clinical efficacy of oral Vitamin D3 on Wound Healing in patients with Chronic Rhinosinusitis With Nasal Polyposis and Lower Vitamin D Levels After Endonasal Endoscopic Sinus Surgery
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin D+Budesonide Nasal Spray | Experimental | Vitamin D 4000IU/day for 8 weeks + Budesonide Nasal Spray 128ug/d for 8 week |
|
| placebo+Budesonide Nasal Spray | Placebo Comparator | Placebo for 8 weeks + Budesonide Nasal Spray128ug/d for 8 week |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin D | Drug | Vitamin D 4000IU/day for 8 weeks |
| |
| Measure | Description | Time Frame |
|---|---|---|
| VAS evaluation of usual symptoms in patients with CRSwNP | The evaluated symptoms were nasal obstruction, anterior nasal discharge and post-nasal drip, smelling reduction and facial pain | at 8 weeks after first drug intake |
| Questionnaire:SNOT-20 evaluates the quality of Life | at 8 weeks after first drug intake | |
| Change of Lund-Kennedy scores | at 8 weeks after first drug intake |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory mediators in serum | 8 weeks | |
| Histologic analysis of nasal mucosa | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jun Tian | Contact | 13603514451 | zguotian@126.com | |
| Ying Y Fang | Contact | 15703410761 | m15703410761@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Hospital of Shanxi Medical University | Recruiting | Taiyuan | Shanxi | China |
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| ID | Term |
|---|---|
| D014807 | Vitamin D |
| D019819 | Budesonide |
| ID | Term |
|---|---|
| D012632 | Secosteroids |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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| Budesonide Nasal Spray |
| Drug |
Budesonide Nasal Spray 128ug/d for 8 week |
|
|
| placebo | Other | placebo for 8 weeks |
|
| D011282 |
| Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |