Dose-dependent Effects of Second-hand Smoke on Vascular Function

Dose-dependent Biological Mechanisms of Second-hand Smoke on Endothelial Function and Oxidative Stress

The purpose of this study is to determine the vascular effects of brief second-hand smoke exposure on normal healthy individuals.

Second-hand smoke remains a significant public health threat. Despite evidence to suggest that secondhand smoke contributes to adverse cardiovascular outcomes, little is known about the dose-dependent vascular effects of brief secondhand smoke exposure at low doses commonly encountered in the community. This study will investigate the acute vascular effects and dose-dependent biological mechanisms of secondhand smoke on endothelial function and oxidative stress.

Inclusion Criteria:

• Healthy non-smoking adults

Exclusion Criteria:

• Reported Active Smoking
• History of diabetes, hypertension, chronic respiratory disease, coronary artery disease, prior myocardial infarction or heart failure
• Pregnancy or breastfeeding
• Current use of prescription drugs within 14 days of trial
• Reported significant passive smoke exposure or elevated cotinine levels