Imaging 61CuATSM Uptake in Atherosclerotic Plaque Using PET-CT

A Mechanistic, Non-randomised Study to Examine the Uptake of a Specific Radionuclide (61CuATSM) in Carotid Artery Plaque

The build up of plaque in the wall of the artery supplying blood to the brain poses a risk of stroke when the plaques become unstable and fragile. It is important to determine which patients are most at risk so that surgery can be performed. There is evidence that the risk is greatest when these plaques become oxygen deficient (hypoxic). The investigators wish to use PET imaging to identify hypoxic plaque, to help decide whether and when to perform surgery. The investigators have developed radiotracers (imaging agents) for this purpose, and this study is to determine whether they will work in patients.

Inclusion Criteria:

• Male/Female patients who are 55yrs or older and for whom carotid endarterectomy is clinically indicated and a decision has been made to perform a carotid endarterectomy.
• Normal liver and adequate renal function. Assessed by measuring eGFR (>50ml/min) and creatinine (<130μmol/L)
• Life expectancy > 12 weeks
• Patients should be able to tolerate head/neck mask as well as lying in the PET-CT scanner

Exclusion Criteria:

• Abnormal liver and renal function (eGFR <50ml/min, Creatinine >130μmol/L)
• Patient unwilling to provide written informed consent