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| Name | Class |
|---|---|
| National Natural Science Foundation of China | OTHER_GOV |
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Carotid atherosclerotic plaque rupture is the main cause of ischemic stroke attacks, and early and precise assessment of plaque vulnerability can prevent ischemic stroke. High-resolution MRI can reflect vulnerable plaque features such as thin fibrous caps and large lipid cores, but cannot assess their metabolic information; Fibro-activated proteins (FAPs) of PET are specifically expressed in atherosclerosis and suggest vulnerable plaques by reflecting inflammation-induced fibrosis. The aim of this study was to apply 18F FDG&68Ga-FAPI PET/MR imaging to investigate the vulnerability of carotid atherosclerotic plaques, to obtain quantitative evaluation indexes of active fibrosis within carotid plaques, and to clarify the PET/MR characteristics of unstable plaques in carotid arteries
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Carotid plaque & carotid atherosclerotic stenosis | Medication or carotid stenting or carotid endarterectomy according to clinical guidelines |
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| Measure | Description | Time Frame |
|---|---|---|
| stroke from baseline to 1months after PET/MR | 1. Incidence of ipsilateral carotid cerebral infarction Incidence within 1 month of standard drug therapy or carotid stenting or carotid endarterectomy | 1 month after PET/MRI |
| stroke from baseline to 6 months after PET/MR | 1. Incidence of ipsilateral carotid cerebral infarction Incidence within 6 month of standard drug therapy or carotid stenting or carotid endarterectomy | 6 month after PET/MRI |
| stroke from baseline to 12 months after PET/MR | 1. Incidence of ipsilateral carotid cerebral infarction Incidence within 12 month of standard drug therapy or carotid stenting or carotid endarterectomy | 12 month after PET/MRI |
| cerebral hemorrhage from baseline to 1months after PET/MR | 1. Incidence of ipsilateral carotid cerebral hemorrhage Incidence within 1 month of standard drug therapy or carotid stenting or carotid endarterectomy | 1 month after PET/MRI |
| Lumen patency rate of ipsilateral carotid artery from baseline to 1 months after PET/MR | 1、The rate of ipsilateral carotid artery lumen patency Observe the rate of lumen patency within 1 month after standard drug therapy or carotid stenting or carotid endarterectomy. | 1 month after PET/MRI |
| Lumen patency rate of ipsilateral carotid artery from baseline to 6 months after PET/MR | 1、The rate of ipsilateral carotid artery lumen patency Observe the rate of lumen patency within 6 month after standard drug therapy or carotid stenting or carotid endarterectomy. |
| Measure | Description | Time Frame |
|---|---|---|
| 18F FDG and 68Ga FAPI PET-MRI imaging results from baseline to 1 months after PET/MRI | 1. Changes in metabolic rate of ipsilateral carotid plaque Changes in metabolic rate of 18F FDG and 68Ga FAPI within 1 month after standard drug therapy or carotid stenting or carotid endarterectomy were observed | 1month after PET/MRI |
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Inclusion Criteria:
-Age between 18 and 80 years; Presence of carotid atherosclerotic plaque confirmed by ultrasound within the past two weeks, with carotid intima-media thickness (IMT) ≥ 2 mm (IMT ≥ 1.2 mm is defined as carotid atherosclerosis) or carotid artery stenosis ≥ 50% as indicated by CTA.
Exclusion Criteria:
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The study included a total of 100 patients with internal carotid artery atherosclerosis, divided into 50 cases in the symptomatic group and 50 cases in the asymptomatic group.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| JUN LIU Professor | Contact | +86-021-64370045 | lj11128@rjh.com.cn | |
| BIN LIU PhD student | Contact | +86-021-64370045 | ousi@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Jun Liu Jun Liu | Department of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Study Chair | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine | Recruiting | Shanghai | Shanghai Municipality | 200025 | China |
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| ID | Term |
|---|---|
| D016893 | Carotid Stenosis |
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D002340 | Carotid Artery Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| 6 month after PET/MRI |
| Lumen patency rate of ipsilateral carotid artery from baseline to 12 months after PET/MR | 1、The rate of ipsilateral carotid artery lumen patency Observe the rate of lumen patency within 12 month after standard drug therapy or carotid stenting or carotid endarterectomy. | 12 month after PET/MRI |
| 18F FDG and 68Ga FAPI PET-MRI imaging results from baseline to 6 months after PET/MRI |
1. Changes in metabolic rate of ipsilateral carotid plaque Changes in metabolic rate of 18F FDG and 68Ga FAPI within 6 month after standard drug therapy or carotid stenting or carotid endarterectomy were observed |
| 6 month after PET/MRI |
| 18F FDG and 68Ga FAPI PET-MRI imaging results from baseline to 12 months after PET/MRI | 1. Changes in metabolic rate of ipsilateral carotid plaque Changes in metabolic rate of 18F FDG and 68Ga FAPI within 12 month after standard drug therapy or carotid stenting or carotid endarterectomy were observed | 12 month after PET/MRI |
| D009422 | Nervous System Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020521 | Stroke |