In the current study, we want to evaluate the prophylactic use of ibuprofen versus a placebo for medical abortion by mifepristone and misoprostol, at a gestational age of up to 7 weeks, in regard to the effect on pain relief and the overall procedure success.

expected results:

The prophylactic use of NSAIDs could offer significant pain relief and thereby a reduction in the need for additional pain relievers compared to the placebo, without interfering with the outcome of medical abortion

Inclusion Criteria:

• Good general health
• Pregnancy of up to 7 weeks gestation.
• Approval from the Ministry of Health committee for termination of pregnancy after an intrauterine pregnancy was demonstrated by an ultrasound exam.
• Subjects that provided informed consent and agree to comply with all study procedures.

Exclusion Criteria:

• Known allergy to mifepristone, misoprostol, paracetamol or NSAIDs.
• Severe anemia.
• Drug or alcohol abuse
• Known abnormal liver function (liver function tests greater than 1.5 times upper range of normal).
• Known abnormal renal function (serum creatinine > 1.5 mg/dl).
• Abnormal blood tests
• Exclusionary health problems contraindicating mifepristone included adrenal disease; sickle cell anemia; severe liver, respiratory, or renal disease; and blood clotting defect.
• Chronic disease
• Patient is participating currently in another clinical trial