Prophylactic Pregabalin to Decrease Pain During Medical Abortion

Prophylactic Pregabalin to Decrease Pain During Medical Abortion: a Randomized Controlled Trial

Medical abortion has been associated with significant pain. The objective of this trial is to determine whether one dose of pregabalin 300 mg, given during medical abortion in addition to the standard of care analgesics, will decrease experienced pain. Investigators will perform a randomized, double-blinded, placebo-controlled trial. Participant pain levels and side effects will be assessed at multiple time points, along with a measure of satisfaction.

Inclusion Criteria:

• Requested and consented for pregnancy termination by medical abortion
• Willing and able to complete multiple electronic surveys

Exclusion Criteria:

• Previous participation in this trial
• Current use of pregabalin or gabapentin
• Contraindication to medical abortion with mifepristone and misoprostol
• Contraindication or allergy to ibuprofen, oxycodone, acetaminophen, or pregabalin
• Unable to understand and sign written informed consents in English