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The purpose of this study is to determine the degree of indirect benefits to family members and classmates resulting from administration of influenza vaccine to children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Influenza vaccination | Active Comparator | Live attenuated influenza vaccine (seasonal and pandemic strains) by nasal spray |
|
| Saline placebo | Placebo Comparator | Saline nasal spray |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trivalent live attenuated seasonal influenza vaccine | Biological | One dose |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical influenza by self-reported symptoms, specifically defined as at least two of fever ≥37.8ºC, cough, headache, sore throat, aches or pains in muscles or joints | One year | |
| Influenza virus infection confirmed by RT-PCR | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Influenza virus infection during the follow-up period assessed by four-fold or greater rise in paired serology. | One year | |
| Adverse events following vaccination | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Benjamin J Cowling, PhD | The University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Hong Kong | Pokfulam | Hong Kong |
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| Monovalent live attenuated pandemic influenza vaccine | Biological | One dose |
|
|
| Saline | Biological | One dose |
|
|
| ID | Term |
|---|---|
| C000613429 | FluMist |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
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