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| Name | Class |
|---|---|
| Los Angeles County Department of Public Health | OTHER_GOV |
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Rates of confirmed influenza illness in vaccinated and non-vaccinated children will be compared between schools with and without vaccination programs. The investigators hypothesize that in addition to lowering rates of influenza in vaccinated children, raising vaccination rates by 30-40% through school-based vaccination programs will decrease incidence of influenza in non-vaccinated children attending those schools compared to non-vaccinated children in schools with low vaccination rates.
This prospective cohort study will evaluate rates of virologically confirmed influenza in children attending schools with and without school-based vaccination programs. Eight schools (4455 students) in two school districts matched for size, race/ethnicity, socioeconomic status, and location will serve as intervention and control schools. During influenza season defined by local surveillance data, nasal/throat swabs will be obtained for rapid influenza detection assays from all children with fever and respiratory symptoms identified by teachers for evaluation in the school nurse's office. Absent children will be offered testing at a central location within the schools' communities.Rates of confirmed influenza illness in vaccinated and non-vaccinated children will be compared between schools with and without vaccination programs. Rates of absenteeism also will be evaluated. The investigators hypothesize that in addition to lowering rates of influenza in vaccinated children, raising vaccination rates by 30-40% through school-based vaccination programs will decrease incidence of influenza in non-vaccinated children attending those schools compared to non-vaccinated children in schools with low vaccination rates.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No Intervention | No Intervention | No school-based influenza vaccination program | |
| Intervention | Active Comparator | School-based Influenza Vaccination Program |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| School-based influenza vaccination program | Biological | School-based influenza vaccination program |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rates of Confirmed Influenza Illness in Vaccinated and Non-vaccinated Children Attending Schools With and Without School-based Influenza Vaccination Programs | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Rates of Absenteeism Among Children Attending Schools With and Without School-based Influenza Vaccination Programs | 1 year |
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Inclusion Criteria:
Exclusion Criteria: none
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| Name | Affiliation | Role |
|---|---|---|
| Pia S Pannaraj, MD, MPH | Childrens Hospital Los Angeles, University of Southern California | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Los Angeles County Department of Public Health | Los Angeles | California | 90012 | United States | ||
| Childrens Hospital Los Angeles |
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| ID | Title | Description |
|---|---|---|
| FG000 | No Intervention | No school-based influenza vaccination program |
| FG001 | Intervention | School-based Influenza Vaccination Program |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | No Intervention | No school-based influenza vaccination program |
| BG001 | Intervention | School-based Influenza Vaccination Program School-based influenza vaccination program: School-based influenza vaccination program |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Rates of Confirmed Influenza Illness in Vaccinated and Non-vaccinated Children Attending Schools With and Without School-based Influenza Vaccination Programs | Posted | Number | flu+ per 1000 children | 1 year |
|
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | No Intervention | No school-based influenza vaccination program |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Pia Pannaraj, MD, MPH | Children's Hospital Los Angeles | 323-361-2509 | ppannaraj@chla.usc.edu |
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| ID | Term |
|---|---|
| D007251 | Influenza, Human |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D009976 | Orthomyxoviridae Infections |
| D012327 | RNA Virus Infections |
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| Los Angeles |
| California |
| 90027 |
| United States |
| BG002 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Full Range | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
|
|
| Secondary | Rates of Absenteeism Among Children Attending Schools With and Without School-based Influenza Vaccination Programs | Posted | Mean | Standard Deviation | days per 100 school days | 1 year |
|
|
|
| 0 |
| 2,087 |
| 0 |
| 2,087 |
| EG001 | Intervention | School-based Influenza Vaccination Program | 0 | 2,368 | 0 | 2,368 |
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| D014777 | Virus Diseases |
| D012140 | Respiratory Tract Diseases |