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The investigators are studying the clinical worth of the serum markers S-100B and NSE in patients with spinal cord injuries e.g. in patients with vertebral fractures. If there is a injury to the neuronal structures these two proteins could be secreted into the serum and add evidence to the severity of the injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | patients with neurological symptoms | ||
| 2 | patients without neurological symptoms |
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| Measure | Description | Time Frame |
|---|---|---|
| Neurological Symptoms | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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patients from daily practice
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| Name | Affiliation | Role |
|---|---|---|
| Vilmos Vecsei, M.D. Professor | Head of Department | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Vienna | State of Vienna | 1090 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17600514 | Background | Loy DN, Kim JH, Xie M, Schmidt RE, Trinkaus K, Song SK. Diffusion tensor imaging predicts hyperacute spinal cord injury severity. J Neurotrauma. 2007 Jun;24(6):979-90. doi: 10.1089/neu.2006.0253. | |
| 16528168 | Background | Marquardt G, Setzer M, Seifert V. Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100 beta. Neurosurgery. 2006 Mar;58(3):E590; author reply E590. doi: 10.1227/01.NEU.0000207967.91316.8D. No abstract available. |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| D016103 | Spinal Fractures |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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Serum probe
| 14699277 | Background | Marquardt G, Setzer M, Seifert V. Protein S-100b for individual prediction of functional outcome in spinal epidural empyema. Spine (Phila Pa 1976). 2004 Jan 1;29(1):59-62. doi: 10.1097/01.BRS.0000103661.78939.02. |
| 15118880 | Background | Marquardt G, Setzer M, Seifert V. Protein S-100b as serum marker for prediction of functional outcome in metastatic spinal cord compression. Acta Neurochir (Wien). 2004 May;146(5):449-52. doi: 10.1007/s00701-004-0242-3. Epub 2004 Mar 22. |
| D014947 | Wounds and Injuries |
| D013124 | Spinal Injuries |
| D019567 | Back Injuries |
| D050723 | Fractures, Bone |