Lung Deposition Via Different Inhalation Devices

A Phase I, Randomized, Open-label, 5-way Crossover, Single Centre Study in Healthy Subjects to Assess the Lung Deposition of Inhaled Budesonide Delivered Via Different Inhalation Devices

The purpose of this study is to assess the deposition of budesonide to the lung after inhalation with 5 different devices and to relate the findings to in vitro properties of inhaled budesonide.

Inclusion Criteria:

• Provision of informed consent prior to any study specific procedures
• BMI between 18 and 30 kg/m2
• Non-smokers/non-snuffers

Exclusion Criteria:

• Pregnant and/or lactating women
• Use of oral contraceptives or hormonal implants
• Known or suspected hypersensitivity to glucocorticosteroids, inhaled lactose, or other excipients in study drugs