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The purpose of this study is to compare if the effect of levobupivacaine on autonomic nervous system smaller than that of bupivacaine.
Obtain the heart rate variability (in means and standard deviation, including the high frequency, low frequency and its ratio) data of before and after spinal anesthesia with ECG (and Heart Rate Variability Analyzer) in 2 groups. Meanwhile, record the blood pressure on each subject.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Levobupivacaine | Active Comparator | Lumbar puncture with Levobupivacaine for spinal anesthesia |
|
| Bupivacaine | Active Comparator | Lumbar puncture with Bupivacaine for spinal anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bupivacaine, levobupivacaine | Drug | intrathecal injection 15~20mg(for Levobupivacaine) or 10~15mg(for Bupivacaine) once |
|
| Measure | Description | Time Frame |
|---|---|---|
| HRV values | 5 minutes after drug administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shih-Yu Chen, M.D. | Contact | 886-5-5323911 | 5202 | hitantc@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Shih-Yu Chen | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, National Taiwan University Hospital, Yun-Lin Branch | Recruiting | Yun-Lin County | 640 | Taiwan |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D000077554 | Levobupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| D000588 |
| Amines |