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| Name | Class |
|---|---|
| University of Oslo | OTHER |
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The purpose of this study is to determine whether dietary intervention with blueberry and grape juice extracts in elderly men with subjective memory problems would raise performance on neuropsychological memory tests and change biomarker of muscle damage and whole blood gene expression profiles.
A number of studies have shown that increased dietary intake of fruits and vegetable extracts high in antioxidants (e.g., blueberries, strawberries and spinach) can retard and even reverse age-related decline in brain function and in cognitive and motor performance in rats. This is the first placebo-controlled human study to evaluate the effect of dietary intake of fruit polyphenols on neuropsychological test scores and whole blood gene regulation
Sixty-two non-demented, non-depressed men (age 67-77 years) with subjective memory decline, were randomly assigned to a blueberry/grape juice- and placebo-group in a 9 week double blind intervention study. Pre- and post treatment assessment were measured with a computerised neuropsychological test battery (CANTAB), including tests for motor speed, visual reaction time, and spatial memory. Dietary habits were registered before intervention and several clinical biomarkers were measured in plasma/serum before and after the intervention. Pre- and post intervention-samples for measurement of gene regulation were also collected
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dietary supplement | Active Comparator | Extracts of bilberry (European blueberries) and red grape juice (Merlot grapes; Vitis Vinifera L.) |
|
| placebo dietary supplement | Placebo Comparator | Placebo juice extracts |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bilberry (European blueberries) and red grape juice | Dietary Supplement | Intervention juice: 50/50 combination of 300 ml bilberry (European blueberries) and red grape juice (Merlot grapes; Vitis Vinifera L.) per day for 9 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| neuropsychological test scores and whole blood gene regulation | December 2006 - july 2007 | |
| whole blood gene regulation; parameters in blood | 2006 and 2007 | |
| neuropsychological test scores; whole blood gene regulation; parameters in blood | 2006 and 2007 |
| Measure | Description | Time Frame |
|---|---|---|
| gene expression of stress, repair and maintenance processes measured by whole genome microarray analysis in blood | 2007 and 2009 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| KJELL - FLEKKOY, DR. PHILOS. | ULLEVAAL UNIVERSITY HOSPITAL; UNIVERSITY OF OSLO | Principal Investigator |
| RUNE - BLOMHOFF, DR. MED. | University of Oslo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ulleval University Hospital HF | Oslo | 0407 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34802467 | Derived | Bohn SK, Myhrstad MCW, Thoresen M, Erlund I, Vasstrand AK, Marciuch A, Carlsen MH, Bastani NE, Engedal K, Flekkoy KM, Blomhoff R. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr. 2021 Nov 22;7(1):75. doi: 10.1186/s40795-021-00482-8. |
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| ID | Term |
|---|---|
| C073305 | Vaccinium myrtillus extract |
| D059808 | Polyphenols |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| placebo juice | Dietary Supplement | Placebo juice: 300 ml, similar to the intervention juice as to taste, energy, salt, and carbohydrates |
|
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |