A Study to Investigate the Food Effect on the Pharmacokinetics of YM178 in Healthy, Non-elderly Volunteers

A Pharmacokinetic Study in Healthy Non-elderly Male and Female Volunteers to Investigate the Effect of Food on the Pharmacokinetics of YM178

The purpose of the study is to evaluate the effect of food intake on the pharmacokinetics of YM178 in healthy, non-elderly adult subjects.

Inclusion Criteria:

• Healthy as judged by the investigator/subinvestigator based on the results of physical examinations and all lab tests
• Body weight (at screening); female ≥40.0 kg, <70.0 kg, male ≥50.0 kg, <80.0 kg
• BMI (at screening): ≥17.6, <26.4
• Written informed consent has been obtained

Exclusion Criteria:

• Received any investigational drugs within 120 days before the screening test
• Donated 400 mL of whole blood within 90 days, 200 mL of whole blood within 30 days, or blood components within 14 days before the screening test
• Received medication within 7 days before hospital admission or is scheduled to receive medication
• Females who are lactating, pregnant, potentially child-bearing, or willing to get pregnant during the study period
• History of drug allergies
• Upper gastrointestinal disease (e.g. nausea, vomiting, stomachache) within 7 days before hospital admission