The purpose of the study is to evaluate the effect of food intake on the pharmacokinetics of YM178 in healthy, non-elderly adult subjects.

Inclusion Criteria:

• Healthy as judged by the investigator/subinvestigator based on the results of physical examinations and all lab tests
• Body weight (at screening); female ≥40.0 kg, <70.0 kg, male ≥50.0 kg, <80.0 kg
• BMI (at screening): ≥17.6, <26.4
• Written informed consent has been obtained

Exclusion Criteria:

• Received any investigational drugs within 120 days before the screening test
• Donated 400 mL of whole blood within 90 days, 200 mL of whole blood within 30 days, or blood components within 14 days before the screening test
• Received medication within 7 days before hospital admission or is scheduled to receive medication
• Females who are lactating, pregnant, potentially child-bearing, or willing to get pregnant during the study period
• History of drug allergies
• Upper gastrointestinal disease (e.g. nausea, vomiting, stomachache) within 7 days before hospital admission