A Long-term Study of YM178 in Symptomatic Overactive Bladder Patients

Long-term Study of YM178: Long Term Study of YM178 in Subjects With Overactive Bladder

The study is intended to test the safety, tolerability, and efficacy of long-term treatment with YM178 in patients with overactive bladder symptoms.

Inclusion Criteria:

• Subject has symptoms of overactive bladder for >= 24 wks
• Subject experiences frequency of micturition at average >= 8 times per 24 hrs confirmed by the 3-day patient diary

Exclusion Criteria:

• Subject is breastfeeding, pregnant, or intends to become pregnant during the study
• Subject obviously has stress incontinence
• Subject has an indwelling catheter or practices intermittent self catheterization
• Subject has evidence of symptomatic urinary tract infection, interstitial cystitis, bladder stone, etc
• Subject has an average total daily urine volume > 3000 mL confirmed by patient diary
• Subject has uncontrollable hypertension (SBP >= 180 mmHg or DBP >= 110 mmHg)