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| ID | Type | Description | Link |
|---|---|---|---|
| CIHR PIN 111846 |
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ethics approval not renewed by Study Group
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| Name | Class |
|---|---|
| Cross Cancer Institute | OTHER |
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The causes of failing nutrition status in advanced cancer are not well known. The way fat is moved, stored, burned or changed into other compounds may be affected and will be followed in patients using a tracer and other blood tests. The investigators hypothesize that fat loss and wasting results from low essential fatty acid availability in the body. Changes may occur in the liver that limits distribution and availability of fat to the body as an energy source or for other essential functions.
Weight loss in cancer is the result of breakdown of fat (lipid) and muscle protein reserves. This research will explore how people with cancer use fat in their body through the use of tracers and measures in the blood. A stable isotope of hydrogen called 'deuterium' is used to trace the production of different fats by the liver. Other methods will determine how much and what types of fat are transported around the body. Body composition will be determined by CT scan and related to fat measures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Metabolism | Lung cancer patients who exhibit abnormalities in lipid measures. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood draws | Other | Up to 4 blood draws will be required, in the amount of about 10 mL each |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of hepatic de novo lipogenesis | 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| Measures of fat transport and availability | 9 months | |
| Resting metabolic rate & fat oxidation | 9 months |
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Inclusion Criteria:
Exclusion Criteria:
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Lung cancer patients
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| Name | Affiliation | Role |
|---|---|---|
| Vera Mazurak, PhD | AHS Cancer Control Alberta | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D002100 | Cachexia |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D003903 | Deuterium |
| D017666 | Deuterium Oxide |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood
| Oral administration of stable isotope (deuterium) |
| Biological |
1 mg deuterium-labeled water/kg body water (loading dose), and 0.5 mg/kg body water diluted in 1 L of normal water (maintenance dose) to be consumed over the following 16 hours |
|
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| Metabolic rate testing | Procedure | Metabolic rate testing is a painless, non-invasive test that takes about 1h. A metabolic cart is used, which detects the amount of oxygen and carbon dioxide the body uses. Patients will lie down on a bed for 30 minutes with lights dimmed and soft music to help them relax. After 30 minutes, a canopy will be placed over the patient's head and shoulders for 30 minutes for the analysis of breath samples. This test will be performed only once for this study. |
|
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D015431 | Weight Loss |
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D013851 | Thinness |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D006859 | Hydrogen |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D005740 | Gases |
| D007554 | Isotopes |
| D014867 | Water |
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |