The Effect of Vitamin K Supplementation on Glucose Metabolism

The Effect of Vitamin K Supplementation on Glucose Metabolism

The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response.

Recently, many studies have reported that vitamin K metabolism is related to glucose metabolism. The suggested mechanisms connecting vitamin K metabolism and glucose metabolism, are inflammation responses and osteocalcin effect on glucose metabolism. Most of the studies have investigated fasting glucose and insulin sensitive index, few have assessed glucose-intake-stimulated responses in regard to vitamin K supplementation. The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response using intravenous glucose tolerance test.

Inclusion Criteria:

• Healthy male volunteer older than 20 years

Exclusion Criteria:

• Subjects with (a history of) diabetes
• Subjects receiving medication related to diabetes or obesity
• Subjects receiving warfarin