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| Name | Class |
|---|---|
| Hennepin Healthcare Research Institute | OTHER |
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This study was intended to evaluate the effect of vitamin D supplementation on insulin sensitivity and pancreatic islet beta-cell function. Our hypothesis was that vitamin D supplementation to normal levels in patients with impaired fasting glucose will result in improved insulin sensitivity and improved beta cell function.
A modified frequently sampled intravenous glucose tolerance (mFSIGT) test was used. On day 0, baseline 22 time point mFSIGT was performed. Subjects were then treated with cholecalciferol (vitamin D3) supplementation - 10,000 IU/day - for 28 consecutive days. mFSIGT was then repeated measuring glucose, insulin and c-peptide at all time points. 25-OH vitamin D, PTH, and calcium were also measured at time point 0 pre and post vitamin D supplementation. Data was analyzed using the Bergman/Boston minimal model for insulin homeostasis with MinMod Millennium software.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Each subject was evaluated and data was collected before and after the intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cholecalciferol (vitamin D3) | Dietary Supplement | Oral capsules of cholecalciferol, 5000 IU/ capsule, two capsules daily for one month. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of insulin sensitivity before and after oral vitamin D3 supplementation with 10,000 IU/day for one month. | At baseline and after 4 weeks of vitamin D supplementation |
| Measure | Description | Time Frame |
|---|---|---|
| Monitor effect of vitamin D supplementation with 10,000 IU/day for one month on serum calcium and parathyroid hormone levels. | One month | |
| Assess effect of vitamin D supplementation on beta cell function as measured by analysis of data collected through a modified FSIGT test. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cary Mariash, MD | University of Minnesota | Study Director |
| Shaban Nazarian, MD | University of Minnesota | Principal Investigator |
| Sidney Jones, MD | University of Minnesota | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota, Division of Endocrinology | Minneapolis | Minnesota | 55455 | United States |
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| ID | Term |
|---|---|
| D011236 | Prediabetic State |
| D014808 | Vitamin D Deficiency |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D002762 | Cholecalciferol |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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| One month |
| D004700 | Endocrine System Diseases |
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
| D006946 | Hyperinsulinism |
| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |