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The purpose of this study was to compare the acute effects of 5g of Cassia cinnamon, 50 minutes of endurance exercise performed at 70% of the heart rate reserve (correlated to VO2max), and 5g of cellulose placebo on blood glucose, serum insulin and insulin sensitivity following an oral glucose tolerance test 3 hours after administration of each intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 5g Cassia cinnamon | Experimental | Experimental treatment group |
|
| 50 minutes endurnace exercise | Active Comparator | Endurance exercise treatment known to influence blood glucose |
|
| 5g Cellulose | Placebo Comparator | Placebo equivalent in weight and appearance to experimental treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cassia cinnamon | Dietary Supplement | 5g encapsulated ground bark administered once in experimental session |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood Glucose | Baseline, 0, 30, 60, 90 and 120 minutes following OGTT |
| Measure | Description | Time Frame |
|---|---|---|
| Serum Insulin | Baseline, 0, 30, 60, 90 and 120 minutes following OGTT |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Darryn S Willoughby, Ph.D. | Baylor University | Study Chair |
| Jean L Gutierrez, Ph.D. | Baylor University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Baylor University Department of Health, Human Performance, and Recreation | Waco | Texas | 76798 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17556692 | Background | Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr. 2007 Jun;85(6):1552-6. doi: 10.1093/ajcn/85.6.1552. | |
| 19158209 | Background | Hlebowicz J, Hlebowicz A, Lindstedt S, Bjorgell O, Hoglund P, Holst JJ, Darwiche G, Almer LO. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009 Mar;89(3):815-21. doi: 10.3945/ajcn.2008.26807. Epub 2009 Jan 21. |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D018149 | Glucose Intolerance |
| D011236 | Prediabetic State |
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 50 minutes exercise | Procedure | 50 minutes treadmill endurance exercise at 70% of the heart rate reserve (correlated to VO2max) |
|
| Cellulose Powder | Dietary Supplement | 5g encapsulated powder administered during placebo experimental session |
|
| 19159947 | Background | Solomon TP, Blannin AK. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 2009 Apr;105(6):969-76. doi: 10.1007/s00421-009-0986-9. Epub 2009 Jan 22. |
| 17924872 | Background | Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 2007 Nov;9(6):895-901. doi: 10.1111/j.1463-1326.2006.00694.x. |
| D006943 | Hyperglycemia |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |