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| Name | Class |
|---|---|
| University of Ulster | OTHER |
| Ulster Hospital, Northern Ireland | UNKNOWN |
| National University of Ireland, Galway, Ireland | OTHER |
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The purpose of this study is to determine whether 3 g cinnamon was sufficient to delay the gastric emptying rate of a high-fat solid meal and subsequently reduce postprandial blood glucose and lipid responses, oxidative stress, arterial stiffness and satiety responses in a healthy adult population.
Cinnamon has been shown to delay gastric emptying (GE) of a high-carbohydrate meal and reduce postprandial glycaemia in healthy adults. However, it is dietary fat which is implicated in the etiology and is associated with obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD). We aimed to determine the effect of 3 g cinnamon on GE, postprandial lipemic and glycemic responses, oxidative stress, arterial stiffness, as well as appetite sensations and subsequent food intake following a high-fat (HF) meal.
The effect of acute oral administration of 3 g cinnamon on gastric emptying of a high-fat pancake test meal and subjective appetite sensations by visual analogue scale will be measured for six hours postprandially. During this time course, measurements of postprandial lipemic, glycemic, oxidative stress and arterial stiffness responses will be collected. Subsequently, food intake will be measured using an ad libitum buffet meal. The study will be conducted in a randomized, placebo-controlled, single-blinded manner in 9 healthy subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dietary supplementation | Experimental | 3g of cinnamon or placebo control were added to a test-meal. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cinnamon | Dietary Supplement | acute oral administration of 3 g cinnamon |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of 3grams cinnamon on gastric emptying half time | During the 6.5 hours post ingestion |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial stiffness | Post-prandial changes in pulse wave velocity (m/s) will be measured non-invasively, using Pulsetrace PSA2 to indicate arterial stiffness. | During the 6.5 hours after ingestion |
| Lipaemia |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Amir Shafat, PhD | Univeristy of Limerick | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Physical Education & Sport Sciences, University of Limerick | Limerick | Ireland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21899741 | Derived | Markey O, McClean CM, Medlow P, Davison GW, Trinick TR, Duly E, Shafat A. Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. Cardiovasc Diabetol. 2011 Sep 7;10:78. doi: 10.1186/1475-2840-10-78. |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| Placebo control |
| Dietary Supplement |
3 g wheat flour (placebo)- separated by 28 days from cinnamon intervention |
|
Plasma concentration (mmol/l) of triacylglycerols, LDL, and HDL will be measured every hour in the post-prandial period.
| During the 6.5 hours after ingestion |
| Glycemia | The concentration of plasma glucose (mmol/l) will measured hourly in the postprandial period, using venous blood drawn from a forearm vein. | During the 6.5 hours after ingestion |
| Appetite | Subjective sensation of hunger, desire to eat, fullness, thirst, tiredness and coldness will be meaured using a 150mm visual analogue scale (mm). | During the 6.5 hours after ingestion |
| Oxidative stress | Serum lipidhydroperoxides will be measured using FOX-1 assay. | During the 6.5 hours after ingestion |
| Food intake | A buffet meal will be presented to the volunteer 6h after breakfast. Food intake will be monitored covertly by weighing individiual food items before and after presentation. Food intake will be expressed as macronutrient (carbohydrate, fat, protein, water, fibre) and energy intake. | 6 hours post-prandially |