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| Name | Class |
|---|---|
| Shandong Provincial Hospital | OTHER_GOV |
| Shandong Cancer Hospital and Institute | OTHER |
| The First Affiliated Hospital of Zhengzhou University | OTHER |
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The purpose of this study is to determine whether cylindrical abdominoperineal resection is effective in the treatment of advanced very low rectal cancer
Abdominoperineal resection (APR) is still a common operation in patients with tumours less than 6 cm from the anal verge. The perineal phase of APR is a difficult part of the operation, often done with the patient in the supine position.The risk of inadvertent bowel perforation is high, the resulting specimen frequently has a waist at the lower border of the mesorectum, and the circumferential resection margin (CRM) is often close to the rectal muscle tube. The cylindrical APR may be performed via an extended posterior perineal approach, that aims to create a more cylindrical specimen without a waist. The potential benefit of this technique is a reduction in the risk of bowel perforation and tumour involvement of the CRM, and thus in the risk of local recurrence.
Perineal wounds in patients following APR are at considerable risk for infection, dehiscence and delayed healing when closed primarily. This can be further increased in patients who have received neoadjuvant chemoradiation therapy. The adoption of extended resection, such as the cylindrical APR, may cause additional risks. The use of acellular biomaterials, including human acellular dermal matrix (HADM) has drawn great interest for the complex abdominal wall reconstruction.
The purpose of this study is to determine whether cylindrical abdominoperineal resection is effective in the treatment of advanced very low rectal cancer, and to determine the initial results of pelvic reconstruction using human acellular dermal matrix after cylindrical abdominoperineal resection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cylindrical abdominoperineal resection | patients underwent cylindrical abdominoperineal resection for advanced very low rectal cancer |
| |
| abdominoperineal resection | patients underwent conventional abdominoperineal resection for advanced very low rectal cancer |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cylindrical abdominoperineal resection | Procedure | Extended abdominoperineal resection with human acellular dermal matrix reconstruction of the pelvic floor for rectal cancer |
|
| Measure | Description | Time Frame |
|---|---|---|
| postoperative complications | 08/01/2011 |
| Measure | Description | Time Frame |
|---|---|---|
| 3-years overall survival | 08/01/2013 |
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Inclusion Criteria:
Exclusion Criteria:
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hospitalized patients with rectal cancer
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhen Jun Wang, M.D. | Contact | 86-013601393711 | wang3zj@sohu.com | |
| Jia Gang Han, M.D. | Contact | 86-013522867841 | wzhj611@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Zhen Jun Wang, M.D. | Beijing Chao Yang Hospital | Study Chair |
| Yong Dai, M.D. | Shandong Provincial Hospital | Principal Investigator |
| Heng Ma, M.D. |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Luhe Hospital | Recruiting | Beijing | Beijing Municipality | 100000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17143848 | Result | Holm T, Ljung A, Haggmark T, Jurell G, Lagergren J. Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancer. Br J Surg. 2007 Feb;94(2):232-8. doi: 10.1002/bjs.5489. |
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| Wuhan University |
| OTHER |
| Shenyang Anorectal Hospital | OTHER |
| Beijing Luhe Hospital | OTHER |
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circumferential resection margin; bowel perforation; cross sectional tissue area outside the internal sphincter; mean distance from the internal sphincter to the anterior, posterior and lateral circumferential resection margins
|
| Shandong Cancer Hospital and Institute |
| Principal Investigator |
| Qun Qian, M.D. | Zhong Nan Hospital, Wuhan University | Principal Investigator |
| Xian Dong Zeng, M.D. | Shenyang Anorectal Hospital | Principal Investigator |
| Jian Hua Cai, M.D. | Beijing Luhe Hospital | Principal Investigator |
| Wei Tang Yuan, M.D. | The First Affiliated Hospital of Zhengzhou University | Principal Investigator |
| General Surgery, Beijing Chao Yang Hospital | Recruiting | Beijing | Beijing Municipality | 100020 | China |
|
| The first Affiliated Hospital of Zhengzhou University | Recruiting | Zhengzhou | Henan | 450003 | China |
|
| Zhongnan Hospital, Wuhan University | Recruiting | Wuhan | Hubei | 430077 | China |
|
| Shenyang Anorectal Hospital | Recruiting | Shenyang | Liaoning | 110002 | China |
|
| General Surgery, Shandong Provincial Hospital | Recruiting | Jinan | Shandong | 250022 | China |
|
| Shandong Cancer Hospital and Institute | Recruiting | Jinan | Shandong | 250117 | China |
|
| ID | Term |
|---|---|
| D012004 | Rectal Neoplasms |
| D011183 | Postoperative Complications |
| D009364 | Neoplasm Recurrence, Local |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009385 | Neoplastic Processes |
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