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| ID | Type | Description | Link |
|---|---|---|---|
| P50HD055782 | U.S. NIH Grant/Contract | View source | |
| P30ES007033 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
| National Institute of Environmental Health Sciences (NIEHS) | NIH |
| Autism Speaks | OTHER |
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Early connections has two broad goals:
Researchers at the University of Washington want to learn more about the benefits of early monitoring and intervention for younger siblings of children with autism spectrum disorders (ASD). The information gained in this study may improve methods of early detection and intervention for infants who may be at risk for developing autism and lead to better outcome for these young children and their families.
Participants include families with a child who has been diagnosed with an autism spectrum disorder or typical development and a younger sibling 12 months old or younger. The study protocol includes: (1) comprehensive infant evaluations at the University of Washington Autism Center at 6-months, 12-months, 18-months and 24-months of age. (2) Developmental screening for the older sibling. (3) Questionnaires and phone interviews for parents. (4) Random assignment to an assessment and monitoring intervention group or a University of Washington intervention group. All families will receive advice regarding appropriate intervention services. Families who are assigned to the UW intervention will take part in a parent delivered intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Assessment & Monitoring | No Intervention | No Intervention. Parent-Child participants in assessment and monitoring visits but does not receive any study provided treatment. | |
| Assessment, Monitoring + Intervention | Experimental | Parent-Child participants in assessment and monitoring visits but also the Promoting First Relationships PFR intervention (http://pfrprogram. Org). PFR is a 10 weekly 60-85 minute in-home visits by a masters level mental health provider trained in the PFR curriculum. The PFR curriculum focuses on increasing parenting sensitivity using attachment theory-informed, strength-based consultation strategies. The curriculum is fully manualized and fidelity was assessed according to the manual. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Assessment, Monitoring & Intervention | Behavioral | Assessment and monitoring at 6, 12, 18 and 24 months; Parent delivered intervention provided between 6 and 12 months. |
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| Measure | Description | Time Frame |
|---|---|---|
| Autism Symptoms | AOSI | 12 months |
| Mullen Receptive Language Scale | Mullen Receptive Language Scale SS | 12 months |
| Communication and Symbolic Behavior Scale | CSBS Total Composite Score | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Parent Child Interaction | NCAST Caregiver Total | 12 months |
| Parent quality of life | Questionnaire on Resources and Stress Total Score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bryan King, MD | University of Washington | Principal Investigator |
| Sara J Webb, PhD | University of Washington | Principal Investigator |
| Annette Estes, PhD | University of Washington | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center on Human Development and Disabilities, University of Washington | Seattle | Washington | 98195 | United States |
Participant level data was submitted to NDAR.
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D003142 | Communication |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D012149 | Restraint, Physical |
| D008722 | Methods |
| ID | Term |
|---|---|
| D032763 | Behavior Control |
| D013812 | Therapeutics |
| D007103 | Immobilization |
| D008919 | Investigative Techniques |
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| Washington State Department of Social and Health Services |
| OTHER |
| Autism Science Foundation | OTHER |
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| 12 months |