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| ID | Type | Description | Link |
|---|---|---|---|
| U54MH066417 | U.S. NIH Grant/Contract | View source | |
| DDTR BD-DD |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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This study will determine the impact of early intervention on the communication and social development of toddlers with autism.
Autism is a condition that affects brain development, often leading to difficulties in social, emotional, and educational functioning. This study will determine whether early intervention can improve such functioning in toddlers with autism.
Each treatment session will last 6 months. Children with an autism spectrum disorder will be enrolled in one of two parallel classes and will receive one of two treatments 4 days a week for the duration of the session. Children in each class will receive the same amount and level of intervention, but with a different goal focus. Treatments will be school- and home-based; parents will receive instruction on administering the at-home part of the treatment. The intervention will include environmental engineering, developmental approaches, adaptations of traditional behavioral approaches, and contemporary behavioral approaches that apply principles of applied behavior analysis in more naturalistic teaching frameworks. A series of measures including scales, interviews, and observations will be used to assess the children at baseline, study completion, and 6 months after study completion. The children will be videotaped during the school-based intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Behavioral Intervention (experimental) |
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| 2 | Active Comparator | Behavioral Intervention 2 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Early intervention blending several tx approaches, w/ focus | Behavioral | Early intervention blending several different treatment approaches, with a focus on certain skills |
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| Measure | Description | Time Frame |
|---|---|---|
| Receptive language skills | Pre-tx, Post-tx, and 6 month follow up | |
| Expressive language skills | Pre-tx, Post-tx, and 6 month follow up |
| Measure | Description | Time Frame |
|---|---|---|
| Social cognitive skills | Pre-tx, Post-tx, and 6 month follow up | |
| Social emotional functioning | Pre-tx, Post-tx, and 6 month follow up | |
| Play skills |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rebecca Landa, PhD | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kennedy Krieger Institute | Baltimore | Maryland | 21211 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21126245 | Derived | Landa RJ, Holman KC, O'Neill AH, Stuart EA. Intervention targeting development of socially synchronous engagement in toddlers with autism spectrum disorder: a randomized controlled trial. J Child Psychol Psychiatry. 2011 Jan;52(1):13-21. doi: 10.1111/j.1469-7610.2010.02288.x. Epub 2010 Dec 3. |
| Label | URL |
|---|---|
| Click here for the Center for Autism and Related Disorders (CARD) at the Kennedy Krieger Institute Web site | View source |
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| ID | Term |
|---|---|
| D001321 | Autistic Disorder |
| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| Early intervention blending several treatment approaches | Behavioral | Early intervention blending several different treatment approaches |
|
| Pre-tx, Post-tx, and 6 month follow up |
| Click here for the Autism and Neuro-Psychiatric Disorders Research at the Kennedy Krieger Institute Web site | View source |