Tolerability and Pharmacokinetics of Metformin and Metformin Extended Release (ER)

Gastric Tolerability and Pharmacokinetics of an Extended Release Metformin and an Immediate Release Metformin

The purpose of this study is to determine the gastric tolerability and the pharmacokinetics of an extended release metformin compared with an immediate release metformin in healthy subjects.

Inclusion Criteria:

• Mexican healthy subjects with normal clinical laboratory test results and imaging (hematology, blood chemistry, urine test, VDRL, Hepatitis B, HIV, chest radiography and electrocardiogram)

Exclusion Criteria:

• Familiar or personal history of diabetes
• History of drug or alcohol abuse within the 2 years prior to the study
• A smoking habit greater than 10 cigarettes per day
• History of allergy to the study drugs
• Intercurrent disease
• Intercurrent treatment with any drug