Pharmacokinetic-Pharmacodynamic Relationship of Metformin in Healthy Volunteers

An Open-label, Parallel Group Clinical Trial to Investigate the Pharmacokinetics/Pharmacodynamics of 250/1000 mg of Metformin IR After Oral Administration in Healthy Male Volunteers

Two doses of metformin with 12 hour interval

• low dose group (375/250 mg)
• high dose group (1000/1000mg)

A study to evaluate and compare the pharmacokinetic-pharmacodynamic relationship between different metformin dose groups.

Inclusion Criteria:

• Age 20 to 45
• Body weight 50 to 100 kg
• fasting serum glucose 70 to 125 mg/dL
• who provide informed consent voluntarily

Exclusion Criteria:

• any significant renal, gastrointestinal, hepatic, and metabolic condition
• any co/prior medication within 14 days of study drug administration