Effect of Light Meal on Pharmacokinetic and Pharmacodynamics of Aliskiren in Patients With Mild to Moderate Hypertension

A Randomized, Single-blind, Parallel Group, Multiple Oral Dose Study to Evaluate the Effect of a Light Meal on the Pharmacokinetics and Pharmacodynamics of Aliskiren Using Market 300 mg Tablet Formulation in Subjects With Mild to Moderate Hypertension

The purpose of this study is to determine the effect of a light meal on the pharmacokinetics and pharmacodynamics of aliskiren in patients with mild to moderate hypertension.

Inclusion Criteria:

• Male or female outpatients, 18 to 65 years of age with mild to moderate hypertension
• Patients who are eligible and able to participate in the study

Exclusion criteria:

• Severe hypertension
• Secondary form of hypertension.
• Type 1 or type 2 diabetes mellitus
• Serum potassium out side laboratory reference range
• Any history of hypertensive encephalopathy or cerebrovascular accident

Other protocol-defined inclusion/exclusion criteria may apply