Pain Relief by Intra-Peritoneal Nebulization of Ropivacaine Under Remifentanil Anesthesia for Gynecological Laparoscopy

Phase 3 Prospective, Randomized, Controlled and Double-blinded Second Trial on Pain Relief by Continuous Intra-peritoneal Nebulization of Ropivacaine Under Remifentanil Anesthesia, During Gynecological Laparoscopic Surgery

In our prospective, randomized, placebo controlled and double-blinded study we will study the efficacy of intraperitoneal ropivacaine nebulization on pain relief during gynecologic laparoscopic surgery. This is a second steady with protocol of general anesthesia used of Remifentanil.

Outcome Measures :

• VAS score
• Use of analgesics during operation and postoperative period

Inclusion Criteria:

• Elective gynecological laparoscopic surgery including unilateral or bilateral salpingo-oophorectomy or ovarian cystectomy
• Patient not participating in other medical study at present or during the last 30 days
• Patient is capable of reading, understanding and signing on an informed consent
• Age 18 years and above
• ASA physical status grade 1-2

Exclusion Criteria:

• Allergy to ropivacaine or other local anesthetics or other medications listed in the protocol
• Acute pelvic inflammatory disease
• Coumadin or aspirin treatment
• Significant arrythmias
• Analgesic treatment for chronic pain
• BMI>35