A Safety Comparison of Iopromide and Iodixanol in Renal Impaired Patients

A Randomized, Double-blinded Comparison of Iopromide and Iodixanol in Renally Impaired Patients Undergoing Cardiac Catheterization

The investigators intend to find out which contrast agent has less kidney toxicity in renal impaired patients undergoing cardiac angiography or percutaneous coronary intervention (PCI).

In the diagnosis and treatment of coronary heart disease, patients should undergo cardiac angiography or percutaneous coronary intervention (PCI). In those procedures, the investigators should use the contrast media, and it may cause kidney toxicity especially in the patients with chronic renal insufficiency.

Inclusion Criteria:

• 18 years old or older
• Plan to undergo Cardiac Catheterization
• Signed ICF
• eGFR: 30~59 mL/min/1.73m2

Exclusion Criteria:

• Pregnancy
• Under dialysis
• Conditions interfering with Cardiac Catheterization
• Participation in other trials
• Allergic to X-ray contrast media
• Administration of any investigational drug within the previous 30 days
• Intra-arterial or intravenous administration of iodinated contrast medium from 7 days before to 72 hours after the administration of study drug
• Left ventricular ejection fraction (LVEF) less than 30% by ultrasound examination
• Intake of any nephrotoxic medications 24 hours before or after the administration of study drug