The purpose of this study is to determine the incidence of contrast induced nephropathy and myocardial tissue reperfusion following iso-osmolar iodixanol or ipo-osmolar iopromide administration in patients with acute myocardial infarction undergoing primary PCI.

This is a multicentric randomized comparison between iso-osmolar and ipo-osmolar contrast agents in patients treated with primary PCI with the evaluation of contrast-induced nephropathy incidence and myocardial tissue reperfusion. The study was designed as a non-inferiority trial.

Inclusion Criteria:

• Men or women aged ≥ 18
• Patients with ST-elevation Myocardial Infarction presenting within 12 hours after the onset of symptoms (18 hours in case of cardiogenic shock), who are scheduled to undergo primary PCI
• Patients who have signed and dated the written informed consent form

Exclusion Criteria:

• Patients in pregnancy or lactation
• Long-term dialysis
• Administration of any investigational drug within the previous 30 days
• Intra-arterial or intravenous administration of iodinated contrast medium from 7 days before to 72 hours after the administration of study drug
• Intake of any nephrotoxic medications 24 hours before or after the administration of study drug
• Contraindications to the study drug or the cardiac catheterization procedure
• Previous participation in this study
• As the discretion of the investigator, the patient has any conditions not appropriate to the usage of iodinated contrast agent or not appropriate to undergo cardiac catheterization procedure