Influence of Dexmedetomidine on a Closed-Loop Anesthesia System

Closed-Loop Delivery of Propofol and Remifentanil: Sparing Effect of Dexmedetomidine

The main objective if to evaluate the sparing effect of dexmedetomidine on the doses of propofol and remifentanil.

Inclusion Criteria:

• male patients scheduled for a general anesthesia

Exclusion Criteria:

• age lower than 18 years
• allergy to propofol, or to soja or to peanuts, or to sufentanil, to remifentanil, or to morphine,or to a myorelaxant or to an excipient,
• hypersensibility to sufentanil, or to remifentanil, or to other derivate of fentanyl,
• history of central nervous system disease,
• patients receiving a psychotropic treatment or an agonist-antagonist opiate,
• hypovolemic patients,
• patients receiving a cardio-vascular treatment,
• expected bleeding surgical procedure,
• simultaneous general and loco-regional anesthesia,
• severe hepatic insufficiency.