Natural History of Atherosclerosis

Natural 1-year History of Atherosclerosis in Asymptomatic Patients With Mild to Moderate Carotid Stenosis

20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.

Inclusion Criteria:

• stable carotid artery disease not requiring revascularization
• asymptomatic carotid artery stenosis < 80% or symptomatic patients with stenosis < 60 %
• prophylactic therapy with aspirin (> 100mg/day, statin, blood pressure therapy if indicated (goal < 130/80 mmHg))
• informed consent

Exclusion Criteria:

• non atherosclerotic occlusive disease (Bürgers disease)
• uncontrolled BP (DBP > 110 mmHg and/or SBP > 200 mmHg)
• hemorrhagic disease or platelet count < 100'000 mm^3
• Known active liver disease (elevations of GPT GOT or increased ammonia)
• impaired renal function (crea > 180 mmol/l)
• pregnancy
• severe claustrophobic reactions
• short - term life - threatening pathology
• physically unable to participate in the study
• compliance not guaranteed