Atherosclerotic Plaque Characterization

Atherosclerotic Plaque Characterization Using Multispectral, Multicontrast High Resolution Cardiovascular Magnetic Resonance Imaging

The purpose of this study is to utilize high-resolution CMR carotid imaging for the characterization of carotid wall volumes and plaque content in patients with clinical significant carotid atherosclerosis. Patients who are scheduled to undergo an imaging procedure will be recruited from the cath lab. Upon enrollment, blood samples conventional and genetic profiling will be collected. For patients undergoing a carotid endarterectomy, tissue from the carotid vessel will be collected during their procedure. Comparison of the MR images with tissue and/or blood samples will be made. Length of time in the study will be approximately 1 day. There will be no study-related patient follow-up.

Inclusion Criteria:

• Age range >17 years of age
• Surgical carotid artery disease
• Provide written informed consent and Authorization for Use/Disclosure of PHI

Exclusion Criteria:

• History of carotid trauma
• History of middle or large vessel vasculitis
• Refusal to provide written informed consent and Authorization for
• Use/Disclosure of PHI