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| ID | Type | Description | Link |
|---|---|---|---|
| EA4/106/08 |
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slow recruiting
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| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
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The purpose of this trial is to study the improvement of cerebral hemodynamics in high risk stroke patients with impaired Cerebrovascular Reserve (CVR) due to high grade stenosis of the internal carotid (ICA) or middle cerebral artery (MCA) by Intense Aerobic Exercise (IAEx).
The primary objective: Intense aerobic exercise (24/8 weeks) improves CVR > 20% measured by Transcranial Doppler (TCD) in patients with hemodynamic relevant intra- or extracranial stenoses by enhanced cerebral arterio- and angiogenesis.
Secondary objectives:
Intense aerobic exercise (24/8 weeks) leads to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sedentary | No Intervention | patients who train after an 8 week observational period | |
| patients who train immediately after enrollment | Active Comparator | patients who train immediately after enrollment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intense aerobic exercise | Behavioral | 3 Units (of at least 30 minutes) of intense aerobic exercise per week for 8 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| change of cerebrovascular reserve capacity | immediately after intervention of 8 weeks, 3 months, 6 months, 12 months Follow up |
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial Progenitor Cells, cyto- and chemokines | after intervention of 8 weeks, 3 months, 6 months, 12 months Follow up | |
| Neuropsychological Testing/ Quality of life | immediately after intervention of 8 weeks, 3 months, 6 months, 12 months Follow up |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre for Stroke Research Berlin, Neurology, Charité Campus Benjamin Franklin | Berlin | 12200 | Germany |
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| ID | Term |
|---|---|
| D003251 | Constriction, Pathologic |
| D009043 | Motor Activity |
| D000092122 | Bronchiolitis Obliterans Syndrome |
| ID | Term |
|---|---|
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
| D000092124 | Organizing Pneumonia |
| D001989 | Bronchiolitis Obliterans |
| D001988 | Bronchiolitis |
| D001991 | Bronchitis |
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D006086 | Graft vs Host Disease |
| D007154 | Immune System Diseases |
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