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Large cerebral vessel occlusion is a common phenomenon in the general population and accounts for 13-35% of ischemic strokes. Chronic stenosis in the large cerebral arteries is associated with cerebral hypoperfusion, cognitive decline and an increased risk of stroke or recurrent stroke, respectively.
Even with upgrowth of surgical or endovascular interventions, mechanical reopening of the occluded vessels is often not possible. Alternative treatment opportunities include minimal-to-moderate blood pressure elevation (typically by ceasing antihypertensives) waiting for collateral circulation to develop spontaneously. Another conservative approach to increase cerebral perfusion is aerobic exercising. Physical activity has shown to lead to cerebral blood flow increase, especially in activated brain areas of healthy human and rat models. However, it is remains unknown, how physiological adaptation to physical activity expresses in persons after stroke due to large vessel occlusion. Herein, it is hypothesized that aerobic exercise facilitates the development of an extensive and functional vascular collateral network in persons with ischemic stroke and perfusion compromise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| aerobic treadmill training | Experimental | Progressive graded, high-intensity aerobic treadmill training is delivered over 36 sessions at a frequency of 3x per week for 30-50 minutes of training per session over a period of 3 months. If possible, the training intensity is progressed from 40% to 80% of heart rate reserve, according to the supervising therapist. |
|
| stretching exercise | Active Comparator | The control intervention includes stretching exercise therapy similarly heart rate controlled within limits up to 20% of heart rate reserve over 36 sessions at a frequency of 3x per week for 30 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic treadmill training | Behavioral | The intervention will be delivered based on the initial exercise testing and graded based by increasing the duration, speed and/or altitude of the treadmill training. |
| Measure | Description | Time Frame |
|---|---|---|
| Brain imaging - cerebrovascular reactivity (CVR) by BOLD-fMRI | Functional brain tissue perfusion and tissue at risk based on cerebrovascular reactivity by blood oxygenation-level dependent functional magnetic resonance imaging (BOLD-fMRI), measured as the percentage BOLD signal change /mmHg CO2. | post-intervention (12 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Brain imaging - intravoxel incoherent motion (IVIM) | Functionality of brain microvasculature by measuring diffusion and perfusion components of tissue based on intravoxel incoherent motion | post-intervention (12 weeks) |
| Brain imaging - NOVA-qMRI |
| Measure | Description | Time Frame |
|---|---|---|
| Concomitant medications | covariate | post-intervention (12 weeks) + follow-up (+3 months) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anne Schwarz, PhD | Contact | +41442555645 | anne.schwarz@usz.ch |
| Name | Affiliation | Role |
|---|---|---|
| Christoph Globas, MD | University Hospital and University of Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ambulante Reha Triemli Zürich | Zurich | Switzerland | ||||
| Klinik Lengg AG |
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D052580 | Muscle Stretching Exercises |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Stretching exercise | Behavioral | Interventions, such as stretching, relaxation, passive soft-tissue technics (excl. manipulation) that do not elevate the heart rate above 20HRR |
|
Blood flow velocity based on non-invasive optimal vessel analysis quantitative magnetic resonance imaging
| post-intervention (12 weeks) |
| Brain imaging - Lesion volume | based on 3D T1 weighted imaging, 3D Fluid-Attenuated Inversion Recovery (FLAIR), Diffusion-Eighted Imaging (DWI) | post-intervention (12 weeks) |
| Brain imaging - Collateral status | Collateral status based on 3D time of flight angiography (TOF) | post-intervention (12 weeks) |
| Exercise stress testing | Cycle ergometer testing with spirometry | post-intervention (12 weeks) |
| Six-Minute Walk Test (6MWT) | Functional walking capacity in meters | post-intervention (12 weeks) + follow-up (+3 months) |
| Ten-Meter Walk Test (10MWT) | Walking speed in m/s | post-intervention (12 weeks) + follow-up (+3 months) |
| Fugl-Meyer Assessment of the Lower Extremity (FMMA-LE) | Stroke-specific motor impairment index to assess lower limb motor function with a total score ranging from 0 to 34 and higher scores indicating better performance. | post-intervention (12 weeks) + follow-up (+3 months) |
| Motricity Index of the Lower Extremity (MI-LE) | Muscle strength assessment of three major muscle groups of the lower extremity with a total score ranging from 0 to 100 and higher scores indicating better performance. | post-intervention (12 weeks) + follow-up (+3 months) |
| 5-Chair-Rise-Test | Functional muscle strength, measured in seconds to complete the task. | post-intervention (12 weeks) + follow-up (+3 months) |
| International Physical Activity Questionnaire (IPAQ) | self-reported physical activity | post-intervention (12 weeks) + follow-up (+3 months) |
| Montreal Cognitive Assessment (MoCA) | Screening assessment of cognitive functions with a maximum score of 30 points. | post-intervention (12 weeks) + follow-up (+3 months) |
| Word list learning | Assessment of memory function | post-intervention (12 weeks) + follow-up (+3 months) |
| Digit Span Test / Corsi block | Assessment verbal and nonverbal working memory | post-intervention (12 weeks) + follow-up (+3 months) |
| Stroop test | Assessment of executive function and inhibition | post-intervention (12 weeks) + follow-up (+3 months) |
| European Quality of Life 5 Dimensions 5 Level (5Q-5D-5L) | Quality of life questionnaire that assesses 5 dimensions (mobility, self-care, usual activities, pain/discomfort and anxiety/depression) on a 5-level scale ranging from 1 - no, 2 - slight, 3 - moderate, 4 - severe to 5 - extreme problems or unstable to. | post-intervention (12 weeks) + follow-up (+3 months) |
| Zurich |
| Switzerland |
|
| University Hospital Zurich | Zurich | Switzerland |
|
| D009422 |
| Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |