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| Name | Class |
|---|---|
| British Heart Foundation | OTHER |
The investigators have previously demonstrated that the administration of insulin in the form of an infusion with additional sugar and potassium may improve cardiovascular performance and reduce biochemical evidence of heart muscle injury in non-diabetic patients undergoing coronary artery surgery. The investigators now seek to demonstrate that similar benefits can be achieved in diabetic patients by administering insulin to maintain as near absolutely normal sugar levels as possible.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Administered with glucose potassium insulin solution to achieve euglycaemia 4.0-6.0 mmol/L |
|
| 2 | No Intervention | Normal departmental practice using dextrose insulin infusion |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glucose potassium insulin solution | Drug | Enhanced glycaemic control in diabetics with glucose-potassium-insulin solution |
|
| Measure | Description | Time Frame |
|---|---|---|
| The difference in the mean left ventricular end-systolic volume index (LVESVI) after CABG and the amount of new permanent injury detected in the late CMRI study | 3 months post CABG |
| Measure | Description | Time Frame |
|---|---|---|
| Glycaemic control will be assessed 2 hours pre-operatively and 72 hours post-operatively. Measurement timings will be standardized allowing comparison of glycaemic control during different time-periods. | 72 hours post CABG |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Robert S Bonser | Contact | 0121 4721311 | 2559 | mailto:Robert.Bonser@uhb.nhs.uk |
| Ashvini Menon | Contact | 07973674826 | ashvini.menon@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Birmingham | Birmingham | West Midlands | B15 2TH | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37526194 | Derived | Bellon F, Sola I, Gimenez-Perez G, Hernandez M, Metzendorf MI, Rubinat E, Mauricio D. Perioperative glycaemic control for people with diabetes undergoing surgery. Cochrane Database Syst Rev. 2023 Aug 1;8(8):CD007315. doi: 10.1002/14651858.CD007315.pub3. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C030396 | glucose-insulin-potassium cardioplegic solution |
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| D004700 | Endocrine System Diseases |