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| Name | Class |
|---|---|
| Eli Lilly and Company | INDUSTRY |
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entGlycemic control has been found to improve clinical outcomes following Coronary Bypass Surgery. This study tests the hypothesis that obtaining tighter glycemic control(80-120mg/dl) as opposed to more moderate control (120-180mg/dl) will further improve outcomes.
150 diabetic patients will be randomized to achieve aggressive glycemic control (80-120mg/dl) vs moderate control (120-180mg/dl) using intravenous insulin infusions beginning at anesthetic induction and continuing for 18 hours following surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1Moderate Glycemic Control | Active Comparator | Patients will receive an insulin drip to keep blood glucose levels between 120-180mg/dl |
|
| 2Aggressive Glycemic Control | Active Comparator | Patients will receive an insulin drip designed to maintain serum glucose between 80-120mg/dl |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IV Insulin drip | Drug | IV insulin drip at 100units insulin in 100ml saline designed to keep blood glucose between 120-180mg/dl |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Hypoglycemia | 24 hours following surgery |
| Measure | Description | Time Frame |
|---|---|---|
| free fatty acid levels | 24 hours following surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Boston Medical Center | Boston | Massachusetts | 02118 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21865944 | Result | Lazar HL, McDonnell MM, Chipkin S, Fitzgerald C, Bliss C, Cabral H. Effects of aggressive versus moderate glycemic control on clinical outcomes in diabetic coronary artery bypass graft patients. Ann Surg. 2011 Sep;254(3):458-63; discussion 463-4. doi: 10.1097/SLA.0b013e31822c5d78. |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D007328 | Insulin |
| ID | Term |
|---|---|
| D011384 | Proinsulin |
| D061385 | Insulins |
| D010187 | Pancreatic Hormones |
| D036361 | Peptide Hormones |
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| Insulin | Drug | IV insulin drip to keep serum glucose between 80-120mg/dl. |
|
| D006728 |
| Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |