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| ID | Type | Description | Link |
|---|---|---|---|
| P50CA090949 | U.S. NIH Grant/Contract | View source | |
| P30CA068485 | U.S. NIH Grant/Contract | View source | |
| VU-VICC-THO-0734 | |||
| VICC-THO-0734 |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
RATIONALE: Studying samples of blood, urine, sputum, mouth cells, and bronchial tissue from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about the development of cancer.
PURPOSE: This laboratory study is looking for molecular markers in predicting lung cancer development using tissue samples from healthy participants.
OBJECTIVES:
OUTLINE: Serum, urine, sputum, and buccal cell samples are collected. Patients also undergo bronchoscopy for collection of bronchial tissue and bronchial brush samples. The samples are used for genomic and proteomic studies to identify new molecular abnormalities specific to the development of lung cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy, non-smokers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| proteomic profiling | Genetic | Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath |
|
| Measure | Description | Time Frame |
|---|---|---|
| Collection of biological specimens to use as controls in the study of lung cancer progression | Specimens are collected from healthy participants with no known risk of lung cancer | Off study date, up to one year |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of new molecular abnormalities specific to the development of squamous cell carcinoma of the lung | off-study date, up to one year | |
| Selection of important genes/proteins differentially expressed between study groups (e.g., normal vs low-grade vs high-grade vs invasive) and between normal smokers vs normal non-smokers |
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DISEASE CHARACTERISTICS:
Healthy participant
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Healthy, non-smokers.
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| Name | Affiliation | Role |
|---|---|---|
| Pierre P. Massion, MD | Vanderbilt-Ingram Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vanderbilt-Ingram Cancer Center - Cool Springs | Nashville | Tennessee | 37064 | United States | ||
| Vanderbilt-Ingram Cancer Center at Franklin |
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| biologic sample preservation procedure | Other | Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath |
|
| laboratory biomarker analysis | Other | Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath |
|
| bronchoscopy | Procedure | Collection of breath condensate. |
|
| off-study date, up to one year |
| Nashville |
| Tennessee |
| 37064 |
| United States |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232-6838 | United States |
| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D002289 | Carcinoma, Non-Small-Cell Lung |
| D055752 | Small Cell Lung Carcinoma |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
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| ID | Term |
|---|---|
| D001999 | Bronchoscopy |
| ID | Term |
|---|---|
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004724 | Endoscopy |
| D003949 | Diagnostic Techniques, Surgical |
| D019060 | Minimally Invasive Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D013510 | Pulmonary Surgical Procedures |
| D019616 | Thoracic Surgical Procedures |
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