The Comparison of Efficacy for Cervical Ripening in Labor Induction Between Titrated and Conventional Oral Misoprostol

The Comparison of Efficacy for Cervical Ripening in Labor Induction Between Titrated and Conventional Oral Misoprostol

The purpose of this study is to compare the efficacy for cervical ripening in labor induction between titrated and conventional oral misoprostol

Inclusion Criteria:

• age 18 years old or more
• singleton pregnancy at 37 weeks gestation or more
• cephalic presentation
• reassuring fetal heart rate pattern
• admission for labor induction due to medical or obstetrical conditions
• bishop score less than 6
• giving consent and having signed the consent form for this study

Exclusion Criteria:

• parity more than 3
• estimated fetal weight more than 3,500 grams
• non-reassuring fetal heart rate pattern
• having contraindication for vaginal delivery
• previous uterine scar
• suspected abruptio placenta with non-reassuring fetal heart rate pattern
• abnormal bleeding per vagina, except bloody show
• PROM
• having underlying cardiac, hepatic, or renal diseases
• having history of allergy to misoprostol or prostaglandin analogues
• cervical dilatation 3 centimeters or more
• uterine contraction 3 times or more in 10 minute