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| Name | Class |
|---|---|
| Riddet Institute | UNKNOWN |
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Hydrolysis of dietary protein may impact their gastrointestinal kinetics and further metabolism. The primary goal of this work was to measure the metabolic fate of intact or hydrolyzed protein using a protein of good nutritional quality, i.e., casein. A second aim of this study was to assess the true ileal digestibility of dietary protein using different methods including the hydrolyzed casein method and to measure its possible effect on endogenous intestinal N losses in humans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intact casein | Experimental | Subjects undergo an intestinal and metabolic exploration following the ingestion of a standard mixed meal containing 15% of energy as 15N-labelled intact casein |
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| Hydrolyzed casein | Experimental | Subjects undergo an intestinal and metabolic exploration following the ingestion of a standard mixed meal containing 15% of energy as 15N-labelled hydrolyzed casein |
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| AA | Experimental | Subjects undergo an intestinal and metabolic exploration following the ingestion of a standard mixed meal containing 15% of energy as a mixture of AA mimicking the composition of casein but devoid in serine |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intestinal and metabolic exploration | Other | Subjects are studied for 8h following the ingestion of a standard meal containing 15% of energy as protein. Intestinal, blood and urine are collected at regular intervals. |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial metabolic fate of dietary N | 0h-1h-2h-3h-4h-5h-6h-7h-8h postprandial |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in ileal digestibility determination according to the method used | 8h postprandial |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de recherche sur volontaires | Bobigny | 93 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31711108 | Derived | Deglaire A, Moughan PJ, Airinei G, Benamouzig R, Tome D. Intact and hydrolyzed casein lead to similar ileal endogenous protein and amino acid flows in adult humans. Am J Clin Nutr. 2020 Jan 1;111(1):90-97. doi: 10.1093/ajcn/nqz268. | |
| 19692493 | Derived | Deglaire A, Fromentin C, Fouillet H, Airinei G, Gaudichon C, Boutry C, Benamouzig R, Moughan PJ, Tome D, Bos C. Hydrolyzed dietary casein as compared with the intact protein reduces postprandial peripheral, but not whole-body, uptake of nitrogen in humans. Am J Clin Nutr. 2009 Oct;90(4):1011-22. doi: 10.3945/ajcn.2009.27548. Epub 2009 Aug 19. |
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| 15N-labelled intact casein | Dietary Supplement | standard mixed meal containing 15% of energy as 15N-labelled intact casein |
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| 15N-labelled hydrolyzed casein | Dietary Supplement | standard mixed meal containing 15% of energy as 15N-labelled hydrolyzed casein |
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| mixture of AA | Dietary Supplement | standard mixed meal containing 15% of energy as a mixture of AA mimicking the composition of casein but devoid in serine |
|