Aldosterone in Diabetic Nephropathy

Effect of Aldosterone Antagonism in the Reduction of Albuminuria and Diastolic Disfunction of Patients With Diabetic Nephropathy.

The purpose of this study is to determine whether spironolactone are effective in the reduction of albuminuria and diastolic disfunction of subjects with diabetic nephropathy.

Inclusion Criteria:

• Diabetic subjects with maximum ten years after diagnostic
• Diabetic nephropathy with albuminuria
• Normal renal function
• Diastolic disfunction
• Taking a IECA or ARA drug family previously

Exclusion Criteria:

• Diabetics subjects with macroangiopathy
• Acute coronary syndrome in the three months before
• Hyperkalemia > 5.5 mEq/L
• Pregnancy