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four adverse events encountered
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To determine if a computerized stop order will reduce the number of concurrent trimethoprim/sulfamethoxazole and warfarin orders accepted through the inpatient electronic ordering system while a patient is hospitalized.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| computerized alert | Experimental | An automatic electronic stop of the tmp/sulfa or warfarin order whenever a resident or nurse practitioner places an order for tmp/sulfa with an already active warfarin order, or when ordering both simultaneously |
|
| 2 Current practice | Other | Current practice of the pharmacist recommending cessation of concurrent warfarin and tmp/sulfa orders |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trimethoprim/Sulfamethoxazole and Warfarin | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reduce concomitant orders for warfarin and tmp/smx | 7 months |
| Measure | Description | Time Frame |
|---|---|---|
| Determine if computerized stop order will increase risk for inadvertent cessation of warfarin | 7 months | |
| Determine if computerized stop order will increase risk of delay of treatment with tmp/sulfa when determined to be necessary for treatment | 7 months |
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Inclusion Criteria:
All resident physicians and nurse practitioners involved in inpatient care.
Exclusion Criteria:
None-
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20876410 | Derived | Strom BL, Schinnar R, Aberra F, Bilker W, Hennessy S, Leonard CE, Pifer E. Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial. Arch Intern Med. 2010 Sep 27;170(17):1578-83. doi: 10.1001/archinternmed.2010.324. |
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| ID | Term |
|---|---|
| D014295 | Trimethoprim |
| D013420 | Sulfamethoxazole |
| D014859 | Warfarin |
| ID | Term |
|---|---|
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000096926 | Benzenesulfonamides |
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| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013424 | Sulfanilamides |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D015110 | 4-Hydroxycoumarins |
| D003374 | Coumarins |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |