This study will evaluate the effects of inhaled fluticasone on cell counts and inflammatory mediators measured in sputum of healthy volunteers following exposure to inhaled lipopolysaccharide.

Inclusion Criteria:

• Female subjects who can have children must have a negative pregnancy test at screening and agree to use two methods of birth control throughout the study
• Male subjects with female partner(s) who can have children agree to use an acceptable method of birth control throughout the study
• Subject is a nonsmoker
• Subject is in generally good health
• Subject is willing to comply with the diet, alcohol, and caffeine study restrictions

Exclusion Criteria:

• Subject is a nursing mother
• Subject has taken oral corticosteroids within 8 weeks or inhaled/nasal corticosteroids within 4 weeks of screening
• Subject has nasal polyps, recent nasal surgery, or an ongoing upper or lower respiratory tract infection
• Subject has a recent history of allergic rhinitis at screening
• Subject has any respiratory disease at screening
• Subject has daily phlegm or a chronic cough
• Subject is unable to refrain from the use of any prescription or non-prescription drugs or herbal remedies during the study
• Subject consumes excessive amounts of alcohol or caffeine
• Subject has had major surgery, or donated or lost 1 unit of blood within 4 weeks of screening
• Subject has a history of stroke, seizures, or major neurological disorders
• Subject regularly uses illicit drugs or has a history of drug/alcohol abuse
• Subject received a vaccination within 3 weeks of screening