PH-797804 LPS Study in Healthy Volunteers

A Randomized, Double-blind, Placebo-controlled, 2-way Crossover Study to Determine the Effects of a Single Oral Dose of Ph-797804 on Induced Sputum Inflammatory Markers Following Inhaled Lipopolysaccharide (Lps) Challenge in Healthy Volunteers

The study was performed to assess the effect of PH-797804 on neutrophils (white cells) in the sputum after a challenge with an endotoxin (inhaled LPS). Neutrophils are a sign of inflammation and PH-797804 is being developed as a potential anti-inflammatory treatment for patients with Chronic Obstructive Pulmonary Disease (COPD).

Inclusion Criteria:

• Healthy male or female (WONCBP), non atopic volunteers aged 18-50 years
• Able to produce sputum

Exclusion Criteria:

• Current Smokers
• Abnormal liver function test
• Respiratory Tract Infection within 4 weeks