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investigator changed location, requires new training effort
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Methods of infertility treatment may involve in vitro fertilization or IVF. Though effective, IVF is complex and expensive. Methods using no gonadotropin hormone stimulation of the ovaries are being compared to mild stimulation doses. The goal of the research is to determine which of these if more suitable as a low cost approach for varying individual patients.
Low cost environment is utilized, but fees are charged.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IVM | Experimental | Early egg retrieval, in vitro maturation, then IVF |
|
| Mild IVF | Active Comparator | Mild gonadotropin and conventional IVF |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| In vitro maturation and in vitro fertilization | Procedure | No gonadotropin, eggs harvested early |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cost effectiveness | two years |
| Measure | Description | Time Frame |
|---|---|---|
| Ongoing pregnancy rates per cycle | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joe B Massey, MD | Batzofin Fertility Services | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Batzofin Fertilty Services | New York | New York | 10016 | United States | ||
| BFS |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18775885 | Background | Son WY, Chung JT, Herrero B, Dean N, Demirtas E, Holzer H, Elizur S, Chian RC, Tan SL. Selection of the optimal day for oocyte retrieval based on the diameter of the dominant follicle in hCG-primed in vitro maturation cycles. Hum Reprod. 2008 Dec;23(12):2680-5. doi: 10.1093/humrep/den332. Epub 2008 Sep 4. | |
| 18616892 | Background |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| D011085 | Polycystic Ovary Syndrome |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
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| ID | Term |
|---|---|
| D005307 | Fertilization in Vitro |
| ID | Term |
|---|---|
| D027724 | Reproductive Techniques, Assisted |
| D012099 | Reproductive Techniques |
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
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| Low doses of gonadotropin stimulation. | Procedure | Gonadotropin followed by conventional IVF |
|
|
| New York |
| New York |
| United States |
| Son WY, Chung JT, Demirtas E, Holzer H, Sylvestre C, Buckett W, Chian RC, Tan SL. Comparison of in-vitro maturation cycles with and without in-vivo matured oocytes retrieved. Reprod Biomed Online. 2008 Jul;17(1):59-67. doi: 10.1016/s1472-6483(10)60294-5. |
| D009369 |
| Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |