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The investigators will examine the balance between IVF success in terms of outcome parameters, using a mild ovarian stimulation protocol, opposing it to the conventional stimulation regimens in poor responders undergoing IVF.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mild ovarian stimulation | Experimental | 100 mg CC by day 2 till 6, plus antagonist plus gonadotrophin 150-200IO until HCG triggering |
|
| conventional ovarian stimulation | Active Comparator | 300-450 IU of FSH starting by day 2 of menstrual cycle together with a fixed dose of GnRH antagonist starting by day 6 till egg recovery, or same doses using a GnRH agonist long protocol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mild ovarian stimulation | Procedure | 100-150 mg of clomiphene citrate from day 2 till day 6 of the cycle and 150 mg of gonadotrophins as soon as 1 follicle is more than 14mm together with 1 fixed dose of GnRH antagonist until egg recovery |
| Measure | Description | Time Frame |
|---|---|---|
| number of oocytes (COCs) | at oocyte recovery |
| Measure | Description | Time Frame |
|---|---|---|
| Number/rate of participants whom the IVF cycle was cancelled | After the 1st week of ovarian stimulation, no oocytes at OR | |
| clinical pregnancy rate | Presence of fetal heart at transvaginal ultrasound at 6 weeks of gestation or 6 weeks after starting the intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 3rd Department of Obstetrics & Gynecology, Assisted Reproduction Unit | Athens | Chaidari | 12462 | Greece |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| conventional ovarian stimulation | Procedure | 300-450 IU of FSH starting by day 2 of menstrual cycle together with a fixed dose of GnRH antagonist starting by day 6 till egg recovery, or same doses with GnRH agonist long protocol |
|
| 6 weeks |
| live birth | more than 20 weeks |
| miscarriage | pregnancy loss before 20 weeks of gestation, after a positive pregnancy test |
| stimulation characteristics | total dose of gonadotropins administered, | from start of stimulation until embryo transfer |
| cancellation rate | when premature ovulation was evident by the loss of follicle(s) prior to oocyte recovery, and in cases where there were no oocytes retrieved or no embryos produced for transfer and in failed fertilization | from start of stimulation until ET |