A study designed to look at how the drug AZD8566 is taken up by the body when given with or without food. In some subjects a comparison will be made with a very small labelled microdose given into a vein.

Inclusion Criteria:

• Provision of written informed consent
• Clinically normal physical findings and laboratory values as judged by the investigator with normal ECG
• Females who are permanently or surgically sterile or post-menopausal and males

Exclusion Criteria:

• History of any convulsions or seizures
• History of infection or risk of infection due to recent surgery or trauma
• History or presence of conditions know to interfere with the absorption, distribution, metabolism and excretion of the study drug